State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun 130021, China.
J Am Chem Soc. 2011 Jun 15;133(23):8778-81. doi: 10.1021/ja200328s. Epub 2011 May 23.
Acid-decomposable, luminescent ZnO quantum dots (QDs) have been employed to seal the nanopores of mesoporous silica nanoparticles (MSNs) in order to inhibit premature drug (doxorubicin) release. After internalization into HeLa cells, the ZnO QD lids are rapidly dissolved in the acidic intracellular compartments, and as a result, the loaded drug is released into the cytosol from the MSNs. The ZnO QDs behave as a dual-purpose entity that not only acts as a lid but also has a synergistic antitumor effect on cancer cells. We anticipate that these nanoparticles may prove to be a significant step toward the development of a pH-sensitive drug delivery system that minimizes drug toxicity.
酸可分解的、发荧光的 ZnO 量子点（QDs）被用来密封介孔硅纳米颗粒（MSNs）的纳米孔，以抑制药物（阿霉素）的过早释放。进入 HeLa 细胞后，ZnO QD 盖子在酸性细胞内环境中迅速溶解，结果负载的药物从 MSNs 释放到细胞质中。ZnO QDs 不仅起到了盖子的作用，而且对癌细胞还有协同的抗肿瘤作用，因此表现为一种双重用途的实体。我们预计这些纳米颗粒可能是朝着开发最小化药物毒性的 pH 敏感药物传递系统迈出的重要一步。
