Clinical Exercise Physiology Laboratory, Department of Kinesiology, Indiana University, Bloomington, IN 47405, USA.
Appl Physiol Nutr Metab. 2011 Jun;36(3):368-75. doi: 10.1139/H11-028. Epub 2011 May 16.
Habitually active adults (ACT) typically exhibit lower postprandial lipemia, a condition that may attenuate oxidative stress and endothelial dysfunction following a high-fat meal (HFM), compared with inactive adults (INA). Our objective was to compare triglycerides (TAG), superoxide dismutase activity (SOD), oxidative stress (thiobarbituric reactive substances; TBARS), and brachial artery flow-mediated dilation (FMD%) before and after an HFM challenge in ACT and INA. ACT (n = 7) and INA (n = 7) subjects were matched for body mass index, age, and sex. Plasma TAG, SOD, TBARS, and FMD% were measured at baseline and 4 h after an HFM challenge. TAG significantly increased following the HFM in INA (4.15 ± 3.79 mmol·L(-1) vs. 8.07 ± 5.12 mmol·L(-1)) and in ACT (2.16 ± 0.55 mmol·L(-1) vs. 3.24 ± 1.40 mmol·L(-1)). Baseline TBARS were greater in ACT and remained unchanged in response to the HFM in both INA (5.1 ± 2.7 mmol·L(-1) vs. 6.9 ± 2.9 mmol·L(-1)) and ACT (8.6 ± 2.0 mmol·L(-1) vs. 7.9 ± 1.9 mmol·L(-1)). ACT exhibited greater SOD than INA at baseline (8.6 ± 0.7 U·mL(-1) vs. 7.8 ± 0.6 U·mL(-1)) and following the HFM (9.3 ± 1.2 U·mL(-1) vs. 8.0 ± 0.7 U·mL(-1)). Postprandial FMD% was decreased in INA (9.1% ± 4.0% vs. 6.2% ± 3.4%), yet remained unchanged in ACT (7.9% ± 3.7% vs. 9.3% ± 3.2%). In conclusion, the differential responses following an HFM support the concept that habitual physical activity can attenuate the negative postprandial alterations that affect vascular health.
习惯性活跃成年人（ACT）通常表现出较低的餐后血脂血症，与不活跃成年人（INA）相比，这种情况可能会减轻高脂肪餐后的氧化应激和内皮功能障碍。我们的目的是比较 ACT 和 INA 在高脂肪餐挑战前后的甘油三酯（TAG）、超氧化物歧化酶活性（SOD）、氧化应激（硫代巴比妥酸反应物质；TBARS）和肱动脉血流介导的扩张（FMD%）。ACT（n=7）和 INA（n=7）受试者在体重指数、年龄和性别方面相匹配。在高脂肪餐挑战前和 4 小时后测量血浆 TAG、SOD、TBARS 和 FMD%。INA（4.15±3.79mmol·L（-1）对 8.07±5.12mmol·L（-1））和 ACT（2.16±0.55mmol·L（-1）对 3.24±1.40mmol·L（-1））的 TAG 在高脂肪餐后显著增加。基线 TBARS 在 ACT 中更高，在 INA 中不变（5.1±2.7mmol·L（-1）对 6.9±2.9mmol·L（-1））和 ACT（8.6±2.0mmol·L（-1）对 7.9±1.9mmol·L（-1）））。ACT 在基线时的 SOD 高于 INA（8.6±0.7U·mL（-1）对 7.8±0.6U·mL（-1））和高脂肪餐后（9.3±1.2U·mL（-1）对 8.0±0.7U·mL（-1））。INA 的餐后 FMD%降低（9.1%±4.0%对 6.2%±3.4%），而 ACT 不变（7.9%±3.7%对 9.3%±3.2%）。结论，高脂肪餐后的不同反应支持习惯性体力活动可以减轻影响血管健康的负面餐后改变的概念。
