Geriatrics Research Education and Clinical Center, Baltimore Veterans Affairs Medical Center, Baltimore, MD 21201, USA.
Med Sci Sports Exerc. 2011 Dec;43(12):2381-7. doi: 10.1249/MSS.0b013e31822432d4.
Maximal or peak aerobic capacity (VO(2peak)) during a maximal-effort graded exercise test is considered by many to be the "gold standard" outcome for assessing the effect of exercise training on cardiorespiratory fitness. The reliability of this measure in Parkinson disease (PD) has not been established, where the degree of motor impairment can vary greatly and is influenced by medications. This study examined the reliability of VO(2peak) during a maximal-effort graded exercise test in subjects with PD.
Seventy healthy middle-aged and older subjects with PD Hoehn and Yahr stage 1.5-3 underwent a screening/acclimatization maximal-effort treadmill test followed by two additional maximal-effort treadmill tests with repeated measurements of VO(2peak). A third VO(2peak) test was performed in a subset of 21 subjects.
The mean VO(2peak) measurement was 2.4% higher in the second test compared with the first test (21.42 ± 4.3 vs 21.93 ± 4.50 mL·kg(-1)·min(-1), mean ± SD, P = 0.03). The intraclass correlation coefficients (ICC) for VO(2peak) expressed either as milliliters per kilogram per minute or as liters per minute were highly reliable, with ICC of 0.90 and 0.94, respectively. The maximum HR (ICC of 0.91) and final speed achieved during the tests (ICC of 0.94) were also highly reliable, with the respiratory quotient being the least reliable of the parameters measured (ICC of 0.65).
Our results demonstrate that measurement of VO(2peak) is reliable and repeatable in subjects with mild to moderate PD, thereby validating use of this parameter for assessing the effects of exercise interventions on cardiorespiratory fitness.
在最大努力分级运动测试中，最大有氧能力（VO2peak）被许多人认为是评估运动训练对心肺适应性影响的“金标准”结果。然而，在帕金森病（PD）中，这种测量的可靠性尚未确定，因为运动障碍的程度差异很大，并且受到药物的影响。本研究旨在检查 PD 患者在最大努力分级运动测试中 VO2peak 的可靠性。
70 名健康的中老年 PD 患者（Hoehn 和 Yahr 分期 1.5-3）接受了筛选/适应最大努力跑步机测试，随后进行了两次额外的最大努力跑步机测试，重复测量 VO2peak。其中 21 名患者进行了第三次 VO2peak 测试。
与第一次测试相比，第二次测试的平均 VO2peak 测量值高 2.4%（21.42 ± 4.3 与 21.93 ± 4.50 mL·kg-1·min-1，平均值 ± 标准差，P = 0.03）。VO2peak 以毫升/千克/分钟或升/分钟表示的组内相关系数（ICC）均高度可靠，分别为 0.90 和 0.94。测试过程中的最大心率（ICC 为 0.91）和最终速度（ICC 为 0.94）也高度可靠，而呼吸商是测量参数中最不可靠的（ICC 为 0.65）。
我们的结果表明，在轻度至中度 PD 患者中，VO2peak 的测量是可靠且可重复的，因此验证了使用该参数评估运动干预对心肺适应性的影响。
