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Stat5: from breast development to cancer prognosis, prediction, and progression.

作者信息

Tweardy David, Chang Jenny C

出版信息

J Clin Oncol. 2011 Jun 20;29(18):2443-4. doi: 10.1200/JCO.2010.34.2014. Epub 2011 May 16.

DOI:10.1200/JCO.2010.34.2014
PMID:21576641
Abstract
摘要

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J Clin Oncol. 2011 Jun 20;29(18):2443-4. doi: 10.1200/JCO.2010.34.2014. Epub 2011 May 16.
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Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure.乳腺癌中核定位和酪氨酸磷酸化 Stat5 的丢失预示着不良的临床结局和增加抗雌激素治疗失败的风险。
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Prognostic or predictive? It's time to get back to definitions!预后还是预测？是时候回归定义了！
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Metastasis tumor antigen family proteins during breast cancer progression and metastasis in a reliable mouse model for human breast cancer.在一种可靠的人类乳腺癌小鼠模型中，转移肿瘤抗原家族蛋白在乳腺癌进展和转移过程中的作用
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Activated Akt signaling pathway in invasive ductal carcinoma of the breast: correlation with HER2 overexpression.乳腺浸润性导管癌中激活的Akt信号通路：与HER2过表达的相关性
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Expression of insulin-like growth factor II in female breast cancer as related to established prognostic factors and long-term prognosis.胰岛素样生长因子II在女性乳腺癌中的表达与既定预后因素及长期预后的关系
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Y-box binding protein, YB-1, as a marker of tumor aggressiveness and response to adjuvant chemotherapy in breast cancer.Y盒结合蛋白YB-1作为乳腺癌肿瘤侵袭性和辅助化疗反应的标志物。
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[Loss of fragile histidine triad expression and metastasis in breast cancer].[脆性组氨酸三联体表达缺失与乳腺癌转移]
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Stem Cell Rev Rep. 2017 Jun;13(3):407-417. doi: 10.1007/s12015-017-9741-5.
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The combination of methylsulfonylmethane and tamoxifen inhibits the Jak2/STAT5b pathway and synergistically inhibits tumor growth and metastasis in ER-positive breast cancer xenografts.甲基磺酰甲烷与他莫昔芬联合使用可抑制Jak2/STAT5b信号通路，并协同抑制雌激素受体阳性乳腺癌异种移植瘤的生长和转移。
BMC Cancer. 2015 Jun 19;15:474. doi: 10.1186/s12885-015-1445-0.
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STAT3 and STAT5b polymorphism contributes to breast cancer risk and clinical outcomes.
信号转导和转录激活因子3（STAT3）及信号转导和转录激活因子5b（STAT5b）基因多态性与乳腺癌风险及临床预后相关。
Int J Clin Exp Pathol. 2015 Feb 1;8(2):2033-8. eCollection 2015.
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Exome analysis reveals differentially mutated gene signatures of stage, grade and subtype in breast cancers.外显子组分析揭示了乳腺癌中分期、分级和亚型的差异突变基因特征。
PLoS One. 2015 Mar 24;10(3):e0119383. doi: 10.1371/journal.pone.0119383. eCollection 2015.
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STAT3 genetic variant, alone and in combination with STAT5b polymorphism, contributes to breast cancer risk and clinical outcomes.信号转导和转录激活因子3（STAT3）基因变异，单独或与信号转导和转录激活因子5b（STAT5b）基因多态性共同作用，会影响乳腺癌风险及临床预后。
Med Oncol. 2015 Jan;32(1):375. doi: 10.1007/s12032-014-0375-z. Epub 2014 Dec 7.
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Cucurbitacin-I inhibits Aurora kinase A, Aurora kinase B and survivin, induces defects in cell cycle progression and promotes ABT-737-induced cell death in a caspase-independent manner in malignant human glioma cells.葫芦素-I抑制极光激酶A、极光激酶B和生存素，诱导细胞周期进程缺陷，并以半胱天冬酶非依赖的方式促进ABT-737诱导的恶性人类胶质瘤细胞死亡。
Cancer Biol Ther. 2015;16(2):233-43. doi: 10.4161/15384047.2014.987548.
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Enhanced T cell lymphoma in NOD.Stat5b transgenic mice is caused by hyperactivation of Stat5b in CD8+ thymocytes.NOD.Stat5b 转基因小鼠中的增强型 T 细胞淋巴瘤是由 CD8+ 胸腺细胞中 Stat5b 的过度激活引起的。
PLoS One. 2013;8(2):e56600. doi: 10.1371/journal.pone.0056600. Epub 2013 Feb 14.
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Reversal of aberrant cancer methylome and transcriptome upon direct reprogramming of lung cancer cells.肺癌细胞的直接重编程导致异常的癌症甲基组和转录组逆转。
Sci Rep. 2012;2:592. doi: 10.1038/srep00592. Epub 2012 Aug 21.
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Hwanggeumchal sorghum induces cell cycle arrest, and suppresses tumor growth and metastasis through Jak2/STAT pathways in breast cancer xenografts.黄根高粱通过 Jak2/STAT 通路诱导乳腺癌异种移植中的细胞周期停滞，并抑制肿瘤生长和转移。
PLoS One. 2012;7(7):e40531. doi: 10.1371/journal.pone.0040531. Epub 2012 Jul 6.
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Methylsulfonylmethane suppresses breast cancer growth by down-regulating STAT3 and STAT5b pathways.甲基磺酰甲烷通过下调 STAT3 和 STAT5b 通路抑制乳腺癌生长。
PLoS One. 2012;7(4):e33361. doi: 10.1371/journal.pone.0033361. Epub 2012 Apr 2.