艾滋病患者使用齐多夫定和更昔洛韦治疗巨细胞病毒性视网膜炎：疗效与毒性
Treatment of cytomegalovirus retinitis with zidovudine and ganciclovir in patients with AIDS: outcome and toxicity.
作者信息
Millar A B, Miller R F, Patou G, Mindel A, Marsh R, Semple S J
机构信息
University College and Middlesex School of Medicine, London.
出版信息
Genitourin Med. 1990 Jun;66(3):156-8. doi: 10.1136/sti.66.3.156.
Abstract
Sixteen patients with the Acquired Immunodeficiency Syndrome (AIDS) and cytomegalovirus retinitis were treated with ganciclovir alone (9 patients) or ganciclovir and zidovudine (6 patients). The duration of effective treatment, that is the number of weeks during which there was no deterioration in visual symptoms or retinal appearance, was comparable in both groups. However, six of the seven patients receiving concurrent therapy had to cease treatment temporarily because of bone marrow toxicity compared with one of the nine patients treated with ganciclovir alone. It is concluded that continuous concurrent therapy with oral zidovudine and intravenous ganciclovir is not possible unless unlimited supportive therapy including blood transfusion, is available.
摘要
16例获得性免疫缺陷综合征（艾滋病）合并巨细胞病毒性视网膜炎的患者接受了更昔洛韦单药治疗（9例）或更昔洛韦与齐多夫定联合治疗（6例）。两组的有效治疗持续时间，即视觉症状或视网膜外观无恶化的周数相当。然而，接受联合治疗的7例患者中有6例因骨髓毒性不得不暂时停止治疗，而单用更昔洛韦治疗的9例患者中只有1例出现这种情况。得出的结论是，除非有包括输血在内的无限制支持治疗，否则口服齐多夫定和静脉注射更昔洛韦的持续联合治疗是不可能的。
相似文献
1
Treatment of cytomegalovirus retinitis with zidovudine and ganciclovir in patients with AIDS: outcome and toxicity.艾滋病患者使用齐多夫定和更昔洛韦治疗巨细胞病毒性视网膜炎：疗效与毒性
Genitourin Med. 1990 Jun;66(3):156-8. doi: 10.1136/sti.66.3.156.
2
Concomitant ganciclovir and zidovudine treatment for cytomegalovirus retinitis in patients with HIV infection: an approach to treatment.
J Acquir Immune Defic Syndr (1988). 1991;4 Suppl 1:S16-21.
3
Ganciclovir therapy for opportunistic cytomegalovirus disease in AIDS.
AIDS Clin Rev. 1990:149-63.
4
Long-term outpatient treatment of CMV retinitis with ganciclovir in AIDS patients.艾滋病患者巨细胞病毒性视网膜炎的更昔洛韦长期门诊治疗。
Br J Ophthalmol. 1989 Dec;73(12):996-1001. doi: 10.1136/bjo.73.12.996.
5
Low frequency maintenance ganciclovir for cytomegalovirus retinitis.
Scand J Infect Dis. 1991;23(1):43-6. doi: 10.3109/00365549109023373.
6
Suppression of cytomegalovirus retinitis in persons with AIDS with high-dose intravenous acyclovir.大剂量静脉注射阿昔洛韦对艾滋病患者巨细胞病毒性视网膜炎的抑制作用。
J Infect Dis. 1991 Oct;164(4):777-80. doi: 10.1093/infdis/164.4.777.
7
Treatment of cytomegalovirus retinitis with intravitreal ganciclovir. Long-term results.玻璃体内注射更昔洛韦治疗巨细胞病毒性视网膜炎。长期结果。
Ophthalmology. 1989 Mar;96(3):367-74. doi: 10.1016/s0161-6420(89)32900-9.
8
Regression of cytomegalovirus retinitis with zidovudine. A clinicopathologic correlation.齐多夫定治疗巨细胞病毒性视网膜炎的消退：临床病理相关性
Arch Ophthalmol. 1989 Jun;107(6):868-74. doi: 10.1001/archopht.1989.01070010890037.
9
Survival of patients with AIDS and cytomegalovirus disease treated with ganciclovir or foscarnet.接受更昔洛韦或膦甲酸钠治疗的艾滋病合并巨细胞病毒病患者的生存率。
AIDS. 1991 Aug;5(8):959-65. doi: 10.1097/00002030-199108000-00006.
10
AIDS-CMV retinitis: Singapore's first cases.艾滋病相关性巨细胞病毒性视网膜炎：新加坡首例病例。
Ann Acad Med Singap. 1990 Nov;19(6):781-7.
引用本文的文献
1
Combination of ganciclovir and granulocyte-macrophage colony-stimulating factor in the treatment of cytomegalovirus retinitis in AIDS patients. The ACTG 073 Team.更昔洛韦与粒细胞巨噬细胞集落刺激因子联合应用治疗艾滋病患者巨细胞病毒性视网膜炎。美国国立过敏和传染病研究所艾滋病临床试验组073团队。
Eur J Clin Microbiol Infect Dis. 1994;13 Suppl 2:S34-40. doi: 10.1007/BF01973600.
2
Antiviral therapy in human immunodeficiency virus infections. Current status (Part II).人类免疫缺陷病毒感染中的抗病毒治疗。现状（第二部分）
Drugs. 1993 May;45(5):637-53. doi: 10.2165/00003495-199345050-00002.
3
Ganciclovir. An update of its therapeutic use in cytomegalovirus infection.更昔洛韦。其在巨细胞病毒感染中治疗应用的最新情况。
Drugs. 1994 Sep;48(3):455-84. doi: 10.2165/00003495-199448030-00009.
4
Three-dimensional analysis of the synergistic cytotoxicity of ganciclovir and zidovudine.更昔洛韦与齐多夫定协同细胞毒性的三维分析
Antimicrob Agents Chemother. 1991 Jun;35(6):1060-5. doi: 10.1128/AAC.35.6.1060.
5
Cytomegalovirus and AIDS.巨细胞病毒与艾滋病
Genitourin Med. 1992 Feb;68(1):60-1. doi: 10.1136/sti.68.1.60-a.
本文引用的文献
1
Ophthalmologic findings in acquired immune deficiency syndrome (AIDS).
Arch Ophthalmol. 1984 Feb;102(2):201-6. doi: 10.1001/archopht.1984.01040030151015.
2
Acquired immune deficiency syndrome. Ocular manifestations.获得性免疫缺陷综合征。眼部表现。
Ophthalmology. 1983 Aug;90(8):859-73. doi: 10.1016/s0161-6420(83)80009-8.
3
Cytomegalovirus retinitis: a manifestation of the acquired immune deficiency syndrome (AIDS).巨细胞病毒性视网膜炎：获得性免疫缺陷综合征（艾滋病）的一种表现。
Br J Ophthalmol. 1983 Jun;67(6):372-80. doi: 10.1136/bjo.67.6.372.
4
Cytomegalovirus retinitis in immunosuppressed hosts. II. Ocular manifestations.
Ann Intern Med. 1980 Nov;93(5):664-70. doi: 10.7326/0003-4819-93-5-664.
5
Ophthalmic involvement in acquired immunodeficiency syndrome.
Ophthalmology. 1984 Sep;91(9):1092-9. doi: 10.1016/s0161-6420(84)34201-4.
6
The efficacy of azidothymidine (AZT) in the treatment of patients with AIDS and AIDS-related complex. A double-blind, placebo-controlled trial.叠氮胸苷（AZT）治疗艾滋病及艾滋病相关综合征患者的疗效。一项双盲、安慰剂对照试验。
N Engl J Med. 1987 Jul 23;317(4):185-91. doi: 10.1056/NEJM198707233170401.
7
Calculating confidence intervals for relative risks (odds ratios) and standardised ratios and rates.计算相对风险（比值比）、标准化比值及率的置信区间。
Br Med J (Clin Res Ed). 1988 May 7;296(6632):1313-6. doi: 10.1136/bmj.296.6632.1313.
8
Use of ganciclovir to treat serious cytomegalovirus infections in patients with AIDS.使用更昔洛韦治疗艾滋病患者的严重巨细胞病毒感染。
J Infect Dis. 1987 Feb;155(2):323-7. doi: 10.1093/infdis/155.2.323.
9
Treatment of cytomegalovirus retinopathy in patients with acquired immunodeficiency syndrome. Use of the experimental drug 9-[2-hydroxy-1-(hydroxymethyl)ethoxymethyl]guanine.
Arch Ophthalmol. 1986 Dec;104(12):1794-800. doi: 10.1001/archopht.1986.01050240068042.
10
Effect of 9-(1,3-dihydroxy-2-propoxymethyl) guanine on serious cytomegalovirus disease in eight immunosuppressed homosexual men.
Ann Intern Med. 1986 Jan;104(1):41-4. doi: 10.7326/0003-4819-104-1-41.
Zotero 插件