A.K. AGARWAL, MD., DPM., Professor & Head, K.G.'s Medical College, Lucknow.
Indian J Psychiatry. 1997 Jan;39(1):70-5.
In an open trial, drug-resistant schizophrenics were treated with clozapine for sixteen weeks. The patients were rated on BPRS, PANSS, Side effects scale and Global Impression Scale at weeks 0. 9 and 16. A battery of base-line investigations were done, and hemogram was repeated at weekly intervals. Of the total 29 patient included. 25 completed the trial. The patients showed significant improvement on both BPRS and PANSS, although the improvement was more in initial weeks than between 9 and 16 weeks. The most common side effects observed were sedation, hypersalivation and tachycardia. Issues of response of clozapine on negative symptoms and a longer duration of the drug therapy are discussed.
在一项开放性试验中，用氯氮平治疗耐药性精神分裂症患者 16 周。在第 0、9 和 16 周时，根据 BPRS、PANSS、副作用量表和总体印象量表对患者进行评分。进行了一系列基线调查，并在每周间隔时重复血常规检查。在总共 29 名患者中，有 25 名完成了试验。尽管在第 9 周至第 16 周之间的改善不如最初几周明显，但患者在 BPRS 和 PANSS 上均有显著改善。最常见的副作用是镇静、唾液分泌过多和心动过速。讨论了氯氮平对阴性症状的反应和更长的药物治疗持续时间的问题。
