Dias João Carlos Pinto, Amato Neto Vicente
Instituto René Rachou, Fundação Oswaldo Cruz, Belo Horizonte, MG, Brazil.
Rev Soc Bras Med Trop. 2011;44 Suppl 2:68-72. doi: 10.1590/s0037-86822011000800011.
Vectorial, transfusion and congenital are considered the main transmission mechanisms in human Chagas disease. Alternative mechanisms are accidental, oral and by organ transplantation. Other hypothetic mechanisms could be by other vectors, sexual, criminal and by means of marsupial anal secretions. The present accorded strategies for prevention are: CONGENITAL: early case detection and immediate treatment. If possible, start during the pre natal period, throughout mothers serology, performing parasitological tests in the new born from positive women. For positive cases, immediate treatment; for those negative babies, conventional serology at the 8th month, treating specifically those with positive results. ACCIDENTAL TRANSMISSION: Rigorous training and utilization of protection equipments. IF accident occurs, immediate disinfection, conventional serology and beginning of specific treatment by ten days. Revision of the serology after 30 days: if positive, extend the treatment until the total dose (60 days or more). ORGAN TRANSPLANTATION: previous serology for donor and receptor. When the former is infected and the last negative, cancel the surgery or install the specific treatment by ten days before the surgery for the donor, followed by the receptor during ten days after the transplantation. ORAL TRANSMISSION: Specific measures are not available, food hygiene is recommended, including the cooking of meats delivered from possible reservoirs. Nowadays, the detection and immediate treatment of the case is recommended, followed by active research of new cases around the detected one.
虫媒传播、输血传播和先天性传播被认为是人类恰加斯病的主要传播机制。其他传播机制包括意外传播、经口传播和器官移植传播。其他可能的传播机制包括通过其他媒介传播、性传播、犯罪传播以及通过有袋动物的肛门分泌物传播。目前公认的预防策略如下:
早期病例检测与及时治疗。若有可能,在孕期进行,通过对母亲进行血清学检测,对血清学阳性母亲所生新生儿进行寄生虫学检测。对于检测阳性的病例,立即进行治疗;对于检测阴性的婴儿,在第8个月进行常规血清学检测,对检测结果阳性的婴儿进行针对性治疗。
进行严格培训并使用防护设备。若发生意外,立即进行消毒、常规血清学检测,并在10天内开始进行特异性治疗。30天后复查血清学:若为阳性,延长治疗至总疗程(60天或更长时间)。
对供体和受体进行术前血清学检测。若供体感染而受体未感染,取消手术;或者在供体手术前10天开始进行特异性治疗,受体在移植后10天内进行治疗。
目前尚无特异性措施,建议保持食品卫生,包括烹饪来自可能传染源的肉类。如今,建议对病例进行检测并及时治疗,随后对已检测出病例周围的新病例进行主动排查。