Laboratory of Physiology and Ethnopharmacology, Department of Biology, Faculty of Sciences, University Mohamed Ist, Boulevard Mohamed IV, 60000 Oujda, Morocco.
Phytother Res. 2012 Feb;26(2):180-5. doi: 10.1002/ptr.3524. Epub 2011 May 17.
The argan tree plays an important socioeconomic and ecologic role in South Morocco. Moreover, there is much evidence for the beneficial effects of virgin argan oil (VAO) on human health. Thus, this study investigated whether administering VAO to rats can prevent the development of diabetes. VAO extracted by a traditional method from the almonds of Argania spinosa (2 mL/kg) was administered orally (for 7 consecutive days) to rats before and during intraperitoneal alloxan administration (75 mg/kg for 5 consecutive days). An alloxan diabetic-induced untreated group and treated by table oil were used as control groups. Body mass, blood glucose and hepatic glycogen were evaluated. In the present study, subchronic treatment with VAO at a dose of 2 mL/kg, before the experimental induction of diabetes, prevented the body mass loss, induced a significant reduction of blood glucose and a significant increase of hepatic glycogen level (p < 0.001) compared with the untreated diabetic group. In conclusion, the present study shows that argan oil should be further investigated in a human study to clarify its possible role in reducing weight loss in diabetics, and even in inhibiting the development or progression of diabetes. This antidiabetic effect could be due to the richness of VAO in tocopherols, phenolic compounds and unsaturated fatty acids.
阿甘树在摩洛哥南部具有重要的社会经济和生态作用。此外，有大量证据表明初榨阿甘油（VAO）对人类健康有益。因此，本研究调查了给大鼠施用 VAO 是否可以预防糖尿病的发生。用传统方法从阿甘树（Argania spinosa）的杏仁中提取的 VAO（2ml/kg），在腹腔注射（连续 5 天，每天 75mg/kg）前和期间通过口服给予大鼠（连续 7 天）。将未经治疗的阿霉素糖尿病诱导组和用表油治疗的组作为对照组。评估了体重、血糖和肝糖原。在本研究中，亚慢性治疗剂量为 2ml/kg 的 VAO，在实验性诱导糖尿病之前给予，与未经治疗的糖尿病组相比，可防止体重减轻，显著降低血糖水平，并显著增加肝糖原水平（p<0.001）。总之，本研究表明，应该在人类研究中进一步研究阿甘油，以阐明其在减轻糖尿病患者体重减轻方面的可能作用，甚至在抑制糖尿病的发生或进展方面的作用。这种抗糖尿病作用可能归因于 VAO 中生育酚、酚类化合物和不饱和脂肪酸的丰富含量。
