人类代谢率和能量消耗中的线粒体 DNA 变异。
Mitochondrial DNA variation in human metabolic rate and energy expenditure.
机构信息
California Pacific Medical Center Research Institute, San Francisco, CA, 94107, USA.
出版信息
Mitochondrion. 2011 Nov;11(6):855-61. doi: 10.1016/j.mito.2011.04.005. Epub 2011 May 9.
Abstract
The role of climate in driving selection of mtDNA as Homo sapiens migrated out of Africa into Eurasia remains controversial. We evaluated the role of mtDNA variation in resting metabolic rate (RMR) and total energy expenditure (TEE) among 294 older, community-dwelling African and European American adults from the Health, Aging and Body Composition Study. Common African haplogroups L0, L2 and L3 had significantly lower RMRs than European haplogroups H, JT and UK with haplogroup L1 RMR being intermediate to these groups. This study links mitochondrial haplogroups with ancestry-associated differences in metabolic rate and energy expenditure.
摘要
气候在人类从非洲迁移到欧亚大陆的过程中对 mtDNA 选择的作用仍然存在争议。我们评估了线粒体 DNA 变异在静息代谢率 (RMR) 和总能量消耗 (TEE) 中的作用，研究对象为来自健康、衰老和身体成分研究的 294 名年龄较大的、居住在社区的非洲裔美国人和欧洲裔美国人。常见的非洲单倍群 L0、L2 和 L3 的 RMR 明显低于欧洲单倍群 H、JT 和 UK，而单倍群 L1 的 RMR 介于这两组之间。本研究将线粒体单倍群与与代谢率和能量消耗相关的遗传起源差异联系起来。
相似文献
1
Mitochondrial DNA variation in human metabolic rate and energy expenditure.人类代谢率和能量消耗中的线粒体 DNA 变异。
Mitochondrion. 2011 Nov;11(6):855-61. doi: 10.1016/j.mito.2011.04.005. Epub 2011 May 9.
2
The association of mitochondrial DNA haplogroups with POAG in African Americans.线粒体 DNA 单倍群与非裔美国人原发性开角型青光眼的关联性。
Exp Eye Res. 2019 Apr;181:85-89. doi: 10.1016/j.exer.2019.01.015. Epub 2019 Jan 15.
3
Endothelial Cell Bioenergetics and Mitochondrial DNA Damage Differ in Humans Having African or West Eurasian Maternal Ancestry.具有非洲或西欧亚母系祖先的人类，其内皮细胞生物能量学和线粒体DNA损伤存在差异。
Circ Cardiovasc Genet. 2016 Feb;9(1):26-36. doi: 10.1161/CIRCGENETICS.115.001308. Epub 2016 Jan 19.
4
Mitochondrial Haplogroups and Risk of Pulmonary Arterial Hypertension.线粒体单倍群与肺动脉高压风险
PLoS One. 2016 May 25;11(5):e0156042. doi: 10.1371/journal.pone.0156042. eCollection 2016.
5
Mitochondrial DNA diversity in the African American population.非裔美国人线粒体DNA的多样性
Mitochondrial DNA. 2015 Jun;26(3):445-51. doi: 10.3109/19401736.2013.840591. Epub 2013 Oct 9.
6
T cell activation markers and African mitochondrial DNA haplogroups among non-Hispanic black participants in AIDS clinical trials group study 384.艾滋病临床试验组研究 384 中非西班牙裔黑人员中 T 细胞激活标志物与非洲线粒体 DNA 单倍群。
PLoS One. 2012;7(8):e43803. doi: 10.1371/journal.pone.0043803. Epub 2012 Aug 27.
7
Molecular and bioenergetic differences between cells with African versus European inherited mitochondrial DNA haplogroups: implications for population susceptibility to diseases.具有非洲与欧洲遗传线粒体DNA单倍群的细胞之间的分子和生物能量差异：对人群疾病易感性的影响。
Biochim Biophys Acta. 2014 Feb;1842(2):208-19. doi: 10.1016/j.bbadis.2013.10.016. Epub 2013 Nov 4.
8
Characterization of human control region sequences of the African American SWGDAM forensic mtDNA data set.非裔美国法医DNA分析协会（SWGDAM）法医线粒体DNA数据集的人类控制区序列特征分析
Forensic Sci Int. 2005 Mar 10;148(2-3):169-79. doi: 10.1016/j.forsciint.2004.06.001.
9
Mitochondrial DNA Haplogroups and Delirium During Sepsis.线粒体 DNA 单倍群与脓毒症期间的谵妄。
Crit Care Med. 2019 Aug;47(8):1065-1071. doi: 10.1097/CCM.0000000000003810.
10
Whole-mtDNA genome sequence analysis of ancient African lineages.古代非洲谱系的全线粒体DNA基因组序列分析。
Mol Biol Evol. 2007 Mar;24(3):757-68. doi: 10.1093/molbev/msl209. Epub 2006 Dec 28.
引用本文的文献
1
Cancer progression through the lens of age-induced metabolic reprogramming.从年龄诱导的代谢重编程角度看癌症进展
Nat Rev Cancer. 2025 Jul 11. doi: 10.1038/s41568-025-00845-4.
2
Maternal resistance exercise increases infant energy expenditure.母亲进行抗阻运动可增加婴儿的能量消耗。
Am J Physiol Endocrinol Metab. 2025 Mar 1;328(3):E354-E361. doi: 10.1152/ajpendo.00414.2024. Epub 2024 Dec 23.
3
A platform to map the mind-mitochondria connection and the hallmarks of psychobiology: the MiSBIE study.一个绘制心智-线粒体连接以及心理生物学标志的平台：MiSBIE 研究。
Trends Endocrinol Metab. 2024 Oct;35(10):884-901. doi: 10.1016/j.tem.2024.08.006. Epub 2024 Oct 9.
4
Joint and Individual Mitochondrial DNA Variation and Cognitive Outcomes in Black and White Older Adults.黑人和白人老年人的关节和个体线粒体 DNA 变异与认知结果。
J Gerontol A Biol Sci Med Sci. 2024 Sep 1;79(9). doi: 10.1093/gerona/glae170.
5
Mitochondrial DNA Haplogroup K Is Protective Against Autism Spectrum Disorder Risk in Populations of European Ancestry.线粒体 DNA 单倍群 K 可降低欧洲人群自闭症谱系障碍风险。
J Am Acad Child Adolesc Psychiatry. 2024 Aug;63(8):835-844. doi: 10.1016/j.jaac.2023.09.550. Epub 2023 Dec 8.
6
Mitochondrial Dysfunction in Attention Deficit Hyperactivity Disorder.注意缺陷多动障碍中的线粒体功能障碍
Eurasian J Med. 2022 Dec;54(Suppl1):187-195. doi: 10.5152/eurasianjmed.2022.22187.
7
African American Females Are Less Metabolically Flexible Compared with Caucasian American Females following a Single High-Fat Meal: A Pilot Study.非裔美国女性在摄入单份高脂肪餐后的代谢灵活性低于白种裔美国女性：一项初步研究。
Int J Environ Res Public Health. 2022 Oct 9;19(19):12913. doi: 10.3390/ijerph191912913.
8
Mitochondrial Phenotype as a Driver of the Racial Dichotomy in Obesity and Insulin Resistance.线粒体表型作为肥胖和胰岛素抵抗种族差异的驱动因素
Biomedicines. 2022 Jun 20;10(6):1456. doi: 10.3390/biomedicines10061456.
9
Role of mitochondrial genetic interactions in determining adaptation to high altitude human population.线粒体遗传相互作用在决定人类对高海拔环境适应中的作用。
Sci Rep. 2022 Feb 7;12(1):2046. doi: 10.1038/s41598-022-05719-5.
10
Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases.线粒体 DNA 变异体调节 N-甲酰甲硫氨酸、蛋白质平衡和晚年发病风险。
Nat Med. 2021 Sep;27(9):1564-1575. doi: 10.1038/s41591-021-01441-3. Epub 2021 Aug 23.
本文引用的文献
1
Mitochondrial-nuclear epistasis: implications for human aging and longevity.线粒体-核互作：对人类衰老和长寿的影响。
Ageing Res Rev. 2011 Apr;10(2):238-52. doi: 10.1016/j.arr.2010.06.003. Epub 2010 Jun 25.
2
Unmasking the causes of multifactorial disorders: OXPHOS differences between mitochondrial haplogroups.揭示多因素疾病的原因：线粒体单倍群之间的 OXPHOS 差异。
Hum Mol Genet. 2010 Sep 1;19(17):3343-53. doi: 10.1093/hmg/ddq246. Epub 2010 Jun 21.
3
Principal-component analysis for assessment of population stratification in mitochondrial medical genetics.主成分分析在评估线粒体医学遗传学中的群体分层。
Am J Hum Genet. 2010 Jun 11;86(6):904-17. doi: 10.1016/j.ajhg.2010.05.005. Epub 2010 May 27.
4
Colloquium paper: bioenergetics, the origins of complexity, and the ascent of man.学术研讨会论文：生物能量学、复杂性的起源以及人类的崛起。
Proc Natl Acad Sci U S A. 2010 May 11;107 Suppl 2(Suppl 2):8947-53. doi: 10.1073/pnas.0914635107. Epub 2010 May 5.
5
Mitochondrial energetics and therapeutics.线粒体能量学与治疗学。
Annu Rev Pathol. 2010;5:297-348. doi: 10.1146/annurev.pathol.4.110807.092314.
6
Human mitochondrial haplogroup H: the highest VO2max consumer--is it a paradox?人类线粒体单倍群 H：最大摄氧量的最大消费者——这是否是一个悖论？
Mitochondrion. 2010 Mar;10(2):102-7. doi: 10.1016/j.mito.2009.11.005. Epub 2009 Nov 10.
7
Energy expenditure and aging.能量消耗与衰老。
Ageing Res Rev. 2010 Jan;9(1):1-11. doi: 10.1016/j.arr.2009.08.002. Epub 2009 Aug 19.
8
Climate shaped the worldwide distribution of human mitochondrial DNA sequence variation.气候塑造了人类线粒体DNA序列变异的全球分布。
Proc Biol Sci. 2009 Oct 7;276(1672):3447-55. doi: 10.1098/rspb.2009.0752. Epub 2009 Jul 8.
9
Correcting for purifying selection: an improved human mitochondrial molecular clock.校正纯化选择：一种改进的人类线粒体分子钟。
Am J Hum Genet. 2009 Jun;84(6):740-59. doi: 10.1016/j.ajhg.2009.05.001. Epub 2009 Jun 4.
10
Ancient mtDNA genetic variants modulate mtDNA transcription and replication.古代线粒体DNA遗传变异调节线粒体DNA转录和复制。
PLoS Genet. 2009 May;5(5):e1000474. doi: 10.1371/journal.pgen.1000474. Epub 2009 May 8.
Zotero 插件