Bi E, Lutkenhaus J
Department of Microbiology, Molecular Genetics, and Immunology, University of Kansas Medical Center, Kansas City 66103.
J Bacteriol. 1990 May;172(5):2765-8. doi: 10.1128/jb.172.5.2765-2768.1990.
Cell division is regulated so that it occurs only once per cell cycle. In Escherichia coli, a rod-shaped bacterium, division normally takes place at the center of the long axis of the cell; however, in the minicell mutant, division can also take place at the cell pole. Such divisions take place at the expense of normal divisions, resulting in an overall increase in nucleated cell length. We report here that increasing the level of FtsZ can completely suppress the cell length of the minicell mutant by increasing the frequency at which cell division events take place. This result suggests that the level of FtsZ controls the frequency of cell division in E. coli.
细胞分裂受到调控，从而在每个细胞周期仅发生一次。在杆状细菌大肠杆菌中，分裂通常发生在细胞长轴的中心；然而，在小细胞突变体中，分裂也可发生在细胞极。这种分裂以正常分裂为代价发生，导致有核细胞长度总体增加。我们在此报告，通过增加细胞分裂事件发生的频率，提高FtsZ水平可完全抑制小细胞突变体的细胞长度。这一结果表明，FtsZ水平控制大肠杆菌中的细胞分裂频率。
