Singh M, Tiwary A K, Kaur G
Ranbaxy Research Labs, Plot No. 20, Sector 18, Gurgaon, India.
Res Pharm Sci. 2010 Jul;5(2):79-87.
The present study was aimed at evaluating the possible use of inter polymer complexed (IPC) films of xanthan gum (XG) and cationic guar gum (CGG) for formulating domperidone bioadhesive films. Formation of bonds between -COO¯ groups of XG and -N(+)(CH(3))(3) groups of CGG was evident in the FTIR spectra of IPC films. Bioadhesive strength of the films was evaluated employing texture analyser. Water uptake studies indicated swelling to be a function of XG concentration in the interpolymer complexes. The bioadhesive films were found to possess neutral pH. In vitro drug release studies and residence time studies indicated that the film comprising CGG:XG (80:20) released 98% of domperidone in 8 h and exhibited a residence time of approximately 8 h. Enhanced bioavailability of domperidone was observed from bioadhesive films as compared to orally administered conventional tablets. Overall, the findings suggest that IPC films of XG and CGG, exhibiting desired bioadhesive strength and enhanced bioavailability of domperidone, can be prepared.
本研究旨在评估黄原胶（XG）与阳离子瓜尔胶（CGG）的聚合物间络合物（IPC）薄膜用于制备多潘立酮生物粘附薄膜的可能性。在IPC薄膜的傅里叶变换红外光谱中，明显可见XG的-COO¯基团与CGG的-N(+)(CH(3))(3)基团之间形成了键。使用质构分析仪评估薄膜的生物粘附强度。吸水研究表明，溶胀是互聚物络合物中XG浓度的函数。发现生物粘附薄膜具有中性pH值。体外药物释放研究和滞留时间研究表明，包含CGG:XG（80:20）的薄膜在8小时内释放了98%的多潘立酮，且滞留时间约为8小时。与口服传统片剂相比，生物粘附薄膜的多潘立酮生物利用度有所提高。总体而言，研究结果表明，可以制备出具有所需生物粘附强度和提高多潘立酮生物利用度的XG和CGG的IPC薄膜。
