Banerjee Indrani, Powis Stephen, Shevlin Mark, Barnes Jacqueline, Soo Audrey, Sutcliffe Alastair G
General and Adolescent Paediatrics Unit, Institute of Child Health, University College London;
Pediatr Rep. 2010 Jun 18;2(1):e7. doi: 10.4081/pr.2010.e7.
This study aimed to study the health of children born to mothers with chronic kidney disease. Twenty-four children born to mothers with chronic kidney disease were compared with 39 matched control children born to healthy mothers without kidney disease. The well-being of each child was individually assessed in terms of physical health, neurodevelopment and psychological health. Families participating with renal disease were more likely to be from lower socio-economic backgrounds. Significantly fewer vaginal deliveries were reported for mothers with renal disease and their infants were more likely to experience neonatal morbidity. Study and control children were comparable for growth parameters and neurodevelopment as assessed by the Griffiths scales. There was no evidence of more stress amongst mothers with renal disease or of impaired bonding between mother and child when compared to controls. However, there was evidence of greater externalizing behavioral problems in the group of children born to mothers with renal disease. Engaging families in such studies is challenging. Nonetheless, families who participated appreciated being asked. The children were apparently healthy but there was evidence in this small study of significant antenatal and perinatal morbidity compared to controls. Future larger multi-center studies are required to confirm these early findings.
本研究旨在探讨慢性肾病母亲所生子女的健康状况。将24名慢性肾病母亲所生子女与39名匹配的健康无肾病母亲所生对照儿童进行比较。从身体健康、神经发育和心理健康方面对每个孩子的健康状况进行了单独评估。患有肾病的参与家庭更有可能来自社会经济背景较低的群体。患有肾病的母亲报告的阴道分娩明显较少，且她们的婴儿更有可能出现新生儿发病情况。根据格里菲斯量表评估，研究组和对照组儿童在生长参数和神经发育方面具有可比性。与对照组相比，没有证据表明患有肾病的母亲压力更大，或母婴之间的情感联系受损。然而，有证据表明，患有肾病母亲所生儿童组存在更多外化行为问题。让家庭参与此类研究具有挑战性。尽管如此，参与的家庭对被邀请表示感激。这些孩子表面上健康，但在这项小型研究中，与对照组相比，有证据表明存在显著的产前和围产期发病情况。未来需要更大规模的多中心研究来证实这些早期发现。
