Ornoy A, Michailevskaya V, Lukashov I, Bar-Hamburger R, Harel S
Laboratory of Teratology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Child Abuse Negl. 1996 May;20(5):385-96. doi: 10.1016/0145-2134(96)00014-2.
In the present investigation we were interested to study the possible role of in-utero exposure to heroin and of the home environmental in the etiology of long-term developmental problems in children born to heroin-dependent parents in comparison to matched controls. The children were examined at .5-6 years of age by a developmental pediatrician and a developmental psychologist using, for the children up to 2.5 years of age, the Bayley Developmental Scales, and for children aged 3-6 years the McCarthy Scales for Children's Abilities. We examined 83 children born to heroin-dependent mothers, and compared the results to those of 76 children born to heroin-dependent fathers and to three control groups; 50 children with environmental deprivation, 50 normal children from families of moderate or high socioeconomic class, without environmental deprivation, and 80 healthy children from kindergartens in Jerusalem. There were five children (6.0%) with significant neurological damage among the children born to heroin-dependent mothers and six (7.9%) children among those born to heroin-dependent fathers. The children born to heroin-dependent mothers had a lower birth weight and a lower head circumference at examination when compared to controls. The children born to heroin-dependent parents also had a high incidence of hyperactivity, inattention, and behavioral problems. The lowest DQ or IQ among the children with cognitive levels above 70 was found in the children with environmental deprivation, next was the DQ or IQ of children born to heroin-dependent fathers, then the DQ or IQ of the children born to heroin-dependent mothers. When the children born to heroin-dependent mothers were divided to those that were adopted at a very young age and to those raised at home, the adopted children were found to function similarly to the controls while those not adopted functioned significantly lower. Our results show that the developmental delay and behavioral disorders observed among children born to drug-dependent parents raised at home may primarily result from severe environmental deprivation and the fact that one or both parents are addicted. The specific role of the in-utero heroin exposure in the determination of the developmental outcome of these children (if they do not have significant neurological damage), seems to be less important in comparison to the home environment.
在本研究中,我们感兴趣的是,与匹配的对照组相比,研究子宫内接触海洛因以及家庭环境在海洛因依赖父母所生孩子的长期发育问题病因中的可能作用。这些孩子在5至6岁时由一名发育儿科医生和一名发育心理学家进行检查,对于2.5岁以下的孩子使用贝利发育量表,对于3至6岁的孩子使用麦卡锡儿童能力量表。我们检查了83名海洛因依赖母亲所生的孩子,并将结果与76名海洛因依赖父亲所生的孩子以及三个对照组的结果进行比较;50名环境剥夺儿童、50名来自中等或高社会经济阶层家庭且无环境剥夺的正常儿童,以及80名来自耶路撒冷幼儿园的健康儿童。在海洛因依赖母亲所生的孩子中有5名(6.0%)有明显的神经损伤,在海洛因依赖父亲所生的孩子中有6名(7.9%)。与对照组相比,海洛因依赖母亲所生的孩子在检查时出生体重较低且头围较小。海洛因依赖父母所生的孩子多动、注意力不集中和行为问题的发生率也很高。在认知水平高于70的孩子中,环境剥夺儿童的发育商(DQ)或智商(IQ)最低,其次是海洛因依赖父亲所生的孩子的DQ或IQ,然后是海洛因依赖母亲所生的孩子的DQ或IQ。当将海洛因依赖母亲所生的孩子分为很小就被收养的孩子和在家抚养的孩子时,发现被收养的孩子功能与对照组相似,而未被收养的孩子功能明显较低。我们的结果表明,在家抚养的药物依赖父母所生孩子中观察到的发育迟缓及行为障碍可能主要是由于严重的环境剥夺以及父母一方或双方成瘾这一事实。与家庭环境相比,子宫内接触海洛因在决定这些孩子(如果他们没有明显的神经损伤)的发育结果方面的具体作用似乎不那么重要。