• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Establishment of a karyotypically normal B-chronic lymphocytic leukemia cell line; evidence of leukemic origin by immunoglobulin gene rearrangement.

作者信息

Saltman D, Bansal N S, Ross F M, Ross J A, Turner G, Guy K

机构信息

Medical Research Council Human Genetics Unit, Edinburgh, Scotland.

出版信息

Leuk Res. 1990;14(4):381-7. doi: 10.1016/0145-2126(90)90167-8.

DOI:10.1016/0145-2126(90)90167-8
PMID:2159091
Abstract

A new Epstein-Barr virus (EBV) transformed cell line was established from a patient with B-chronic lymphocytic leukemia (B-CLL). The karyotype of the cell line has remained normal for over 12 months in culture; however, identical heavy and light chain immunoglobulin (Ig) gene rearrangements in the patient's blood and the cell line provided evidence that the EBV transformed cells were derived from the neoplastic clone.

摘要

相似文献

1
Establishment of a karyotypically normal B-chronic lymphocytic leukemia cell line; evidence of leukemic origin by immunoglobulin gene rearrangement.
Leuk Res. 1990;14(4):381-7. doi: 10.1016/0145-2126(90)90167-8.
2
Z-138: a new mature B-cell acute lymphoblastic leukemia cell line from a patient with transformed chronic lymphocytic leukemia.
Leuk Res. 1998 Apr;22(4):341-53. doi: 10.1016/s0145-2126(97)00191-4.
3
Epstein-Barr virus (EBV) can immortalize B-cll cells activated by cytokines.爱泼斯坦-巴尔病毒（EBV）可使由细胞因子激活的B细胞永生化。
Leukemia. 1994 Mar;8(3):476-84.
4
The establishment of cell lines from chronic B cell leukaemias: evidence of leukaemic origin by karyotypic abnormalities and Ig gene rearrangement.慢性B细胞白血病细胞系的建立：通过核型异常和Ig基因重排证明白血病起源
Clin Exp Immunol. 1988 Jul;73(1):23-8.
5
Richter's syndrome with identical immunoglobulin gene rearrangements in the chronic lymphocytic leukemia and the supervening non-Hodgkin lymphoma.慢性淋巴细胞白血病及随后发生的非霍奇金淋巴瘤中具有相同免疫球蛋白基因重排的里氏综合征。
Leukemia. 1989 Nov;3(11):819-24.
6
Cytokines and Epstein Barr virus (EBV) genes expression in blood chronic lymphocytic leukaemia (CLL) cells and their immortalised CLL cell lines.细胞因子和爱泼斯坦-巴尔病毒（EBV）基因在血液慢性淋巴细胞白血病（CLL）细胞及其永生化CLL细胞系中的表达。
Anticancer Res. 2003 Sep-Oct;23(5A):4017-22.
7
Conserved patterns of somatic mutation and secondary VH gene rearrangement create aberrant Ig-encoding genes in Epstein-Barr virus-transformed and normal human B lymphocytes.体细胞突变和继发性重链可变区（VH）基因重排的保守模式在爱泼斯坦-巴尔病毒转化的和正常人B淋巴细胞中产生异常的免疫球蛋白编码基因。
Int Immunol. 1992 Feb;4(2):197-206. doi: 10.1093/intimm/4.2.197.
8
Somatic diversification and selection of immunoglobulin heavy and light chain variable region genes in IgG+ CD5+ chronic lymphocytic leukemia B cells.IgG+ CD5+ 慢性淋巴细胞白血病B细胞中免疫球蛋白重链和轻链可变区基因的体细胞多样化与选择
J Exp Med. 1995 Apr 1;181(4):1507-17. doi: 10.1084/jem.181.4.1507.
9
Heterogeneous immunoglobulin gene rearrangement in a B-chronic lymphocytic leukemia progressing into non-Hodgkin lymphoma (Richter syndrome).一例进展为非霍奇金淋巴瘤（里氏综合征）的B细胞慢性淋巴细胞白血病中的异质性免疫球蛋白基因重排
Cancer. 1993 Jan 15;71(2):359-63. doi: 10.1002/1097-0142(19930115)71:2<359::aid-cncr2820710215>3.0.co;2-3.
10
A translocation t(8;14) and c-myc gene rearrangement associated with the histological transformation of B-cell acute lymphocytic leukemia (FAB-L2) into Burkitt's type (FAB-L3) leukemia.一种与B细胞急性淋巴细胞白血病（FAB-L2）组织学转化为伯基特型（FAB-L3）白血病相关的t(8;14)易位和c-myc基因重排。
Leuk Lymphoma. 1997 Oct;27(3-4):357-63. doi: 10.3109/10428199709059691.

引用本文的文献

1
Purine Nucleotide Alterations in Tumoral Cell Lines Maintained with Physiological Levels of Folic Acid.肿瘤细胞系在生理水平叶酸维持下的嘌呤核苷酸改变。
Int J Mol Sci. 2023 Aug 8;24(16):12573. doi: 10.3390/ijms241612573.
2
Peptide-guided targeting of GPR55 for anti-cancer therapy.用于抗癌治疗的肽引导性靶向GPR55
Oncotarget. 2017 Jan 17;8(3):5179-5195. doi: 10.18632/oncotarget.14121.
3
CLL-cell-mediated MDSC induction by exosomal miR-155 transfer is disrupted by vitamin D.维生素D可破坏外泌体miR-155转移介导的慢性淋巴细胞白血病细胞诱导髓源性抑制细胞生成的过程。
Leukemia. 2017 Apr;31(4):985-988. doi: 10.1038/leu.2016.378. Epub 2016 Dec 23.
4
Gene expression profile induced by arsenic trioxide in chronic lymphocytic leukemia cells reveals a central role for heme oxygenase-1 in apoptosis and regulation of matrix metalloproteinase-9.三氧化二砷诱导慢性淋巴细胞白血病细胞产生的基因表达谱揭示了血红素加氧酶-1在细胞凋亡及基质金属蛋白酶-9调控中的核心作用。
Oncotarget. 2016 Dec 13;7(50):83359-83377. doi: 10.18632/oncotarget.13091.
5
miR-181b as a therapeutic agent for chronic lymphocytic leukemia in the Eµ-TCL1 mouse model.在Eµ-TCL1小鼠模型中，miR-181b作为慢性淋巴细胞白血病的治疗剂。
Oncotarget. 2015 Aug 14;6(23):19807-18. doi: 10.18632/oncotarget.4415.
6
Identification of a STAT5 target gene, Dpf3, provides novel insights in chronic lymphocytic leukemia.鉴定出 STAT5 的一个靶基因 Dpf3，为慢性淋巴细胞白血病提供了新的见解。
PLoS One. 2013 Oct 14;8(10):e76155. doi: 10.1371/journal.pone.0076155. eCollection 2013.
7
Concurrent epigenetic silencing of wnt/β-catenin pathway inhibitor genes in B cell chronic lymphocytic leukaemia.B 细胞慢性淋巴细胞白血病中 Wnt/β-连环蛋白通路抑制剂基因的共发生表观遗传沉默。
BMC Cancer. 2012 Jun 6;12:213. doi: 10.1186/1471-2407-12-213.
8
Correction of PCR-bias in quantitative DNA methylation studies by means of cubic polynomial regression.通过三次多项式回归校正定量 DNA 甲基化研究中的 PCR 偏倚。
Nucleic Acids Res. 2011 Jun;39(11):e77. doi: 10.1093/nar/gkr213. Epub 2011 Apr 12.
9
Detection of EBV, HBV, HCV, HIV-1, HTLV-I and -II, and SMRV in human and other primate cell lines.在人和其他灵长类细胞系中检测EB病毒、乙肝病毒、丙肝病毒、人类免疫缺陷病毒1型、人类嗜T淋巴细胞病毒I型和II型以及猿猴泡沫病毒。
J Biomed Biotechnol. 2010;2010:904767. doi: 10.1155/2010/904767. Epub 2010 Apr 29.
10
Engineered anti-CD20 antibodies with enhanced complement-activating capacity mediate potent anti-lymphoma activity.工程化抗 CD20 抗体增强补体激活能力，介导强大的抗淋巴瘤活性。
Cancer Sci. 2009 Dec;100(12):2411-8. doi: 10.1111/j.1349-7006.2009.01327.x. Epub 2009 Aug 25.