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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany.

Biochem J. 1990 Apr 15;267(2):467-70. doi: 10.1042/bj2670467.

In isolated perfused rat liver and in vivo, up to 25% of [3H]leukotriene B4 was eliminated from the circulation via hepatic uptake and biliary excretion within 1 h. Total body recovery of 3H amounted to about 60% of infused [3H]leukotriene B4. 2. Hepatobiliary excretion of leukotriene B4 and its metabolites exceeded renal elimination by about 4-fold and depended, in contrast with excretion of cysteinyl leukotriene E4, upon continuous taurocholate supply. 3. Analyses of bile, liver and recirculated perfusate using h.p.l.c. indicated that the liver metabolized leukotriene B4 extensively to omega-carboxyleukotriene B4 and its beta-oxidized derivatives, and no unmetabolized leukotriene B4 appeared in bile. These results substantiate the important contribution of the hepatobiliary system with respect to the metabolic fate of leukotriene B4.

在离体灌注大鼠肝脏和体内，1小时内高达25%的[3H]白三烯B4通过肝脏摄取和胆汁排泄从循环中清除。3H的全身回收率约为注入的[3H]白三烯B4的60%。2. 白三烯B4及其代谢产物的肝胆排泄比肾脏排泄约高4倍，与半胱氨酰白三烯E4的排泄不同，它依赖于持续供应牛磺胆酸盐。3. 使用高效液相色谱法分析胆汁、肝脏和再循环灌注液表明，肝脏将白三烯B4广泛代谢为ω-羧基白三烯B4及其β-氧化衍生物，胆汁中未出现未代谢的白三烯B4。这些结果证实了肝胆系统对白三烯B4代谢命运的重要贡献。

Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany.

Biochem J. 1990 Apr 15;267(2):467-70. doi: 10.1042/bj2670467.

In isolated perfused rat liver and in vivo, up to 25% of [3H]leukotriene B4 was eliminated from the circulation via hepatic uptake and biliary excretion within 1 h. Total body recovery of 3H amounted to about 60% of infused [3H]leukotriene B4. 2. Hepatobiliary excretion of leukotriene B4 and its metabolites exceeded renal elimination by about 4-fold and depended, in contrast with excretion of cysteinyl leukotriene E4, upon continuous taurocholate supply. 3. Analyses of bile, liver and recirculated perfusate using h.p.l.c. indicated that the liver metabolized leukotriene B4 extensively to omega-carboxyleukotriene B4 and its beta-oxidized derivatives, and no unmetabolized leukotriene B4 appeared in bile. These results substantiate the important contribution of the hepatobiliary system with respect to the metabolic fate of leukotriene B4.

在离体灌注大鼠肝脏和体内，1小时内高达25%的[3H]白三烯B4通过肝脏摄取和胆汁排泄从循环中清除。3H的全身回收率约为注入的[3H]白三烯B4的60%。2. 白三烯B4及其代谢产物的肝胆排泄比肾脏排泄约高4倍，与半胱氨酰白三烯E4的排泄不同，它依赖于持续供应牛磺胆酸盐。3. 使用高效液相色谱法分析胆汁、肝脏和再循环灌注液表明，肝脏将白三烯B4广泛代谢为ω-羧基白三烯B4及其β-氧化衍生物，胆汁中未出现未代谢的白三烯B4。这些结果证实了肝胆系统对白三烯B4代谢命运的重要贡献。