白三烯B4在大鼠体内的肝脏摄取及代谢情况
Hepatic uptake and metabolic disposition of leukotriene B4 in rats.
作者信息
Hagmann W, Korte M
机构信息
Division of Tumor Biochemistry, Deutsches Krebsforschungszentrum, Heidelberg, Federal Republic of Germany.
出版信息
Biochem J. 1990 Apr 15;267(2):467-70. doi: 10.1042/bj2670467.
Abstract
- In isolated perfused rat liver and in vivo, up to 25% of [3H]leukotriene B4 was eliminated from the circulation via hepatic uptake and biliary excretion within 1 h. Total body recovery of 3H amounted to about 60% of infused [3H]leukotriene B4. 2. Hepatobiliary excretion of leukotriene B4 and its metabolites exceeded renal elimination by about 4-fold and depended, in contrast with excretion of cysteinyl leukotriene E4, upon continuous taurocholate supply. 3. Analyses of bile, liver and recirculated perfusate using h.p.l.c. indicated that the liver metabolized leukotriene B4 extensively to omega-carboxyleukotriene B4 and its beta-oxidized derivatives, and no unmetabolized leukotriene B4 appeared in bile. These results substantiate the important contribution of the hepatobiliary system with respect to the metabolic fate of leukotriene B4.
摘要
- 在离体灌注大鼠肝脏和体内，1小时内高达25%的[3H]白三烯B4通过肝脏摄取和胆汁排泄从循环中清除。3H的全身回收率约为注入的[3H]白三烯B4的60%。2. 白三烯B4及其代谢产物的肝胆排泄比肾脏排泄约高4倍，与半胱氨酰白三烯E4的排泄不同，它依赖于持续供应牛磺胆酸盐。3. 使用高效液相色谱法分析胆汁、肝脏和再循环灌注液表明，肝脏将白三烯B4广泛代谢为ω-羧基白三烯B4及其β-氧化衍生物，胆汁中未出现未代谢的白三烯B4。这些结果证实了肝胆系统对白三烯B4代谢命运的重要贡献。
相似文献
1
Hepatic uptake and metabolic disposition of leukotriene B4 in rats.白三烯B4在大鼠体内的肝脏摄取及代谢情况
Biochem J. 1990 Apr 15;267(2):467-70. doi: 10.1042/bj2670467.
2
Characteristics of sinusoidal uptake and biliary excretion of cysteinyl leukotrienes in perfused rat liver.灌注大鼠肝脏中半胱氨酰白三烯的正弦摄取和胆汁排泄特征
Eur J Biochem. 1990 Jul 20;191(1):251-5. doi: 10.1111/j.1432-1033.1990.tb19117.x.
3
Metabolism of cysteinyl leukotrienes in non-recirculating rat liver perfusion. Hepatocyte heterogeneity in uptake and biliary excretion.半胱氨酰白三烯在大鼠非再循环肝脏灌注中的代谢。肝细胞在摄取和胆汁排泄方面的异质性。
Eur J Biochem. 1989 Apr 15;181(1):115-24. doi: 10.1111/j.1432-1033.1989.tb14701.x.
4
Halothane metabolism. Impairment of hepatic omega-oxidation of leukotrienes in vivo and in vitro.氟烷代谢。体内和体外白三烯肝ω-氧化的损伤。
Eur J Biochem. 1992 Jun 15;206(3):869-79. doi: 10.1111/j.1432-1033.1992.tb16995.x.
5
6
Metabolism of leukotrienes B4 and C4 in the isolated perfused rat lung.白三烯B4和C4在离体灌注大鼠肺中的代谢。
J Biol Chem. 1984 Dec 10;259(23):14437-40.
7
Hypoxia and CCl4-induced liver injury, but not acidosis, impair metabolism of cysteinyl leukotrienes in perfused rat liver.缺氧和四氯化碳诱导的肝损伤，而非酸中毒，会损害灌注大鼠肝脏中半胱氨酰白三烯的代谢。
Hepatology. 1990 May;11(5):866-73. doi: 10.1002/hep.1840110523.
8
Hereditary defect of hepatobiliary cysteinyl leukotriene elimination in mutant rats with defective hepatic anion excretion.肝脏阴离子排泄缺陷的突变大鼠中肝胆胱氨酰白三烯清除的遗传性缺陷
Hepatology. 1987 Mar-Apr;7(2):224-8. doi: 10.1002/hep.1840070204.
9
Characteristics of the uptake of cysteine-containing leukotrienes by isolated hepatocytes.分离的肝细胞对含半胱氨酰白三烯的摄取特性。
Biochim Biophys Acta. 1983 Jul 13;732(1):69-74. doi: 10.1016/0005-2736(83)90187-6.
引用本文的文献
1
Synthesis and Significance of Arachidonic Acid, a Substrate for Cyclooxygenases, Lipoxygenases, and Cytochrome P450 Pathways in the Tumorigenesis of Glioblastoma Multiforme, Including a Pan-Cancer Comparative Analysis.花生四烯酸的合成与意义，其作为环氧化酶、脂氧合酶和细胞色素P450途径的底物在多形性胶质母细胞瘤发生中的作用，包括泛癌比较分析
Cancers (Basel). 2023 Feb 2;15(3):946. doi: 10.3390/cancers15030946.
2
Catalytic characterization and cytokine mediated regulation of cytochrome P450 4Fs in rat hepatocytes.大鼠肝细胞中细胞色素P450 4Fs的催化特性及细胞因子介导的调控
Arch Biochem Biophys. 2007 May 1;461(1):104-12. doi: 10.1016/j.abb.2007.02.027. Epub 2007 Mar 15.
3
Impaired degradation of leukotrienes in patients with peroxisome deficiency disorders.过氧化物酶体缺乏症患者中白三烯降解受损。
J Clin Invest. 1993 Mar;91(3):881-8. doi: 10.1172/JCI116309.
4
Metabolic disposition of leukotriene B4 (LTB4) and oxidation-resistant analogues of LTB4 in conscious rabbits.白三烯B4（LTB4）及其抗氧化类似物在清醒兔体内的代谢分布
Br J Pharmacol. 1994 Jun;112(2):654-8. doi: 10.1111/j.1476-5381.1994.tb13125.x.
本文引用的文献
1
Distribution and metabolism of 3H-labeled leukotriene C3 in the mouse.3H标记的白三烯C3在小鼠体内的分布与代谢
J Biol Chem. 1982 Jan 10;257(1):531-5.
2
The biologically active leukotrienes. Biosynthesis, metabolism, receptors, functions, and pharmacology.生物活性白三烯：生物合成、代谢、受体、功能及药理学
J Clin Invest. 1984 Apr;73(4):889-97. doi: 10.1172/JCI111312.
3
Properties of leukotriene B4 20-hydroxylase from polymorphonuclear leukocytes.来自多形核白细胞的白三烯B4 20-羟化酶的特性。
J Biol Chem. 1984 Mar 10;259(5):3082-9.
4
Leukotriene B4 metabolism by hepatic cytochrome P-450.肝脏细胞色素P-450对白三烯B4的代谢
Biochem Biophys Res Commun. 1983 Jul 29;114(2):850-4. doi: 10.1016/0006-291x(83)90859-8.
5
Characteristics of the uptake of cysteine-containing leukotrienes by isolated hepatocytes.分离的肝细胞对含半胱氨酰白三烯的摄取特性。
Biochim Biophys Acta. 1983 Jul 13;732(1):69-74. doi: 10.1016/0005-2736(83)90187-6.
6
Formation of novel hydroxylated eicosatetraenoic acids in preparations of human polymorphonuclear leukocytes.人多形核白细胞制剂中新型羟基化二十碳四烯酸的形成。
FEBS Lett. 1981 Jun 15;128(2):329-35. doi: 10.1016/0014-5793(81)80110-x.
7
Role of peptide leukotrienes and their hepatobiliary elimination in endotoxin action.肽白三烯及其肝胆清除在内毒素作用中的作用。
Circ Shock. 1984;14(4):223-35.
8
Metabolism of leukotriene B4 in the monkey. Identification of the principal nonvolatile metabolite in the urine.白三烯B4在猴子体内的代谢。尿液中主要非挥发性代谢物的鉴定。
Prostaglandins. 1984 Jun;27(6):899-911. doi: 10.1016/s0090-6980(84)80009-x.
9
Leukotrienes as mediators in tissue trauma.白三烯作为组织创伤中的介质。
Science. 1985 Oct 18;230(4723):330-2. doi: 10.1126/science.4048937.
10
Leukotriene B4 omega-hydroxylase in human polymorphonuclear leukocytes. Partial purification and identification as a cytochrome P-450.人多形核白细胞中的白三烯B4 ω-羟化酶。部分纯化及细胞色素P-450鉴定
J Clin Invest. 1985 Sep;76(3):1218-28. doi: 10.1172/JCI112077.
Zotero 插件