类风湿关节炎中的血清铜和红细胞超氧化物歧化酶
Serum copper and erythrocyte superoxide dismutase in rheumatoid arthritis.
作者信息
Banford J C, Brown D H, Hazelton R A, McNeil C J, Sturrock R D, Smith W E
出版信息
Ann Rheum Dis. 1982 Oct;41(5):458-62. doi: 10.1136/ard.41.5.458.
Abstract
Serum copper and thiol levels an caeruloplasmin activity were determined and compared with measurements of articular index, erythrocyte sedimentation rate, and zinc and haemoglobin levels in patients with rheumatoid arthritis. Superoxide dismutase activity, thiol, zinc, and copper levels of haemolysate were measured and compared with each other and to the above parameters. In serum, caeruloplasmin activity increased and thiol levels decreased, whereas in the haemolysate superoxide dismutase activity decreased and thiol levels increased. It is suggested that the changes in copper levels and in the activities of process which may be copper-dependent between plasma and cytosol in patients with rheumatoid arthritis reflect a change in oxidative status of the blood which may have implications in the pathogenesis of the disease.
摘要
测定了类风湿性关节炎患者的血清铜、硫醇水平及铜蓝蛋白活性，并与关节指数、红细胞沉降率、锌和血红蛋白水平的测量结果进行了比较。测量了溶血产物的超氧化物歧化酶活性、硫醇、锌和铜水平，并将它们相互比较以及与上述参数进行比较。在血清中，铜蓝蛋白活性增加而硫醇水平降低，而在溶血产物中，超氧化物歧化酶活性降低而硫醇水平增加。有人提出，类风湿性关节炎患者血浆和细胞溶质中铜水平的变化以及可能依赖铜的过程的活性变化反映了血液氧化状态的改变，这可能对该疾病的发病机制有影响。
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