Jaffe Food Allergy Institute, Department of Pediatrics, Division of Allergy and Immunology, Mount Sinai School of Medicine, New York, NY, USA.
Expert Rev Clin Immunol. 2011 May;7(3):317-27. doi: 10.1586/eci.11.13.
Food protein-induced enterocolitis syndrome (FPIES) is an under-recognized and frequently misdiagnosed non-IgE-mediated food hypersensitivity disorder, characterized by severe vomiting and/or diarrhea. Despite the potential severity of acute reactions, FPIES can be considered self-limiting as avoidance of the incriminating allergen(s) leads to resolution of symptoms. Symptoms typically begin in the first month of life in association with failure to thrive and may progress to acidemia and shock. Although FPIES is well established as a distinct clinical entity, its pathophysiology has not yet been clearly defined and requires further characterization. Several immunologic alterations have been reported in FPIES, suggesting the involvement of antigen-specific T cells and their production of proinflammatory cytokines that regulate the permeability of the intestinal barrier. Humoral immune responses may also be involved in the pathomechanism of FPIES. The aim of this article is to delineate the immunological characteristics of this disorder based on the existing reports and to review the possible pathophysiologic basis of this disease.
食物蛋白诱导的肠炎综合征（FPIES）是一种未被充分认识且经常被误诊的非 IgE 介导的食物过敏反应，其特征为严重呕吐和/或腹泻。尽管急性反应可能很严重，但 FPIES 可被认为是自限性的，因为避免了可疑过敏原可导致症状缓解。症状通常在生命的第一个月与生长不良相关开始，并可能进展为酸中毒和休克。尽管 FPIES 已被明确为一种独特的临床实体，但它的发病机制尚未明确，需要进一步阐明。在 FPIES 中已经报道了几种免疫改变，提示抗原特异性 T 细胞及其产生的调节肠道屏障通透性的促炎细胞因子的参与。体液免疫反应也可能参与 FPIES 的发病机制。本文的目的是根据现有报道描述该疾病的免疫学特征，并综述该病可能的病理生理基础。
