Department of Neurology, University of Technology Dresden, Fetscherstraße 74, D-01307 Dresden, Germany.
J Neurol Sci. 2011 Nov 15;310(1-2):9-11. doi: 10.1016/j.jns.2011.04.016. Epub 2011 May 19.
Parkinson's disease is not only a movement disorder: non-motor symptoms such as loss of smell, constipation, depression, cognitive impairment, sleep problems and disturbances of the autonomic nervous system also feature. The etiology is still unknown, although an increasing number of gene-related Parkinsonian syndromes have been identified. It is intriguing to speculate that PD starts by the intake of a toxin, bacteria or virus. This idea stems from the fact that pathological abnormalities such as Lewy neuritis, Lewy bodies and alpha-synuclein accumulation are first found in the enteric nervous system of the gut and in the olfactory bulb. There is increasing evidence that the disease may spread out from the enteric nervous system of the gut via the vagal nerve up to the brain. Here we present data from animal work which supports this assumption.
它还具有非运动症状，如嗅觉丧失、便秘、抑郁、认知障碍、睡眠问题和自主神经系统紊乱。尽管已经发现了越来越多与基因相关的帕金森综合征，但病因仍不清楚。人们推测 PD 可能是由毒素、细菌或病毒的摄入引起的。这一观点源于这样一个事实，即路易神经炎、路易体和α-突触核蛋白积累等病理异常首先出现在肠道的肠神经系统和嗅球中。越来越多的证据表明，这种疾病可能通过迷走神经从肠道的肠神经系统传播到大脑。在这里，我们呈现了支持这一假设的动物研究数据。
