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外鼻基底细胞癌:手术技术概述及312例患者分析

Basal cell carcinoma of the outer nose: overview on surgical techniques and analysis of 312 patients.

作者信息

Wollina Uwe, Bennewitz Annett, Langner Dana

机构信息

Department of Dermatology and Allergology, Academic Teaching Hospital Dresden-Friedrichstadt, Dresden, Saxony, Germany.

出版信息

J Cutan Aesthet Surg. 2014 Jul;7(3):143-50. doi: 10.4103/0974-2077.146660.

Abstract

BACKGROUND

Basal cell carcinoma of the nose is common, with a potential of local recurrence and high-risk features.

MATERIALS AND METHODS

We provide a review on anatomy of the nose, tumour surgery and defect closure on the nose. We analysed our own patients with nasal BCC of a 24 months period.

RESULTS

We identified 321 patients with nasal BCC. There was a predominance of female patients of 1.2 to 1. The mean age was 74.8 years. Slow Mohs technique was employed for all tumours until 3D tumour-free margins were achieved. That resulted on average in 1.8 ± 0.7 Mohs stages. The most common histologic types were solitary (n = 182), morpheic (79), and micronodular (20), Perineural infiltration was evident in 56 tumours. Primary closure after mobilisation of soft tissue was possible in 105 BCCs. Advancement flaps were used in 91 tumours, rotation flaps in 47, transposition flaps in 34 tumours, and combined procedures in 6 cases. In 36 patients full-thickness skin grafting was performed. In two patients healing by second intention was preferred. Partial flap loss was seen in four patients (1.4%). All of them had significant underlying pathologies. None of the tumours treated showed a relapse during the observation time. However, this is a limitation of the present study since follow-up was on average only 10 months.

CONCLUSIONS

BCCs of the nose are common. Only 3D-controlled micrographic surgery (Mohs or slow Mohs) guarantee a high rate of complete tumour removal and a very low risk of recurrence.

摘要

背景

鼻基底细胞癌很常见,具有局部复发的可能性和高危特征。

材料与方法

我们对鼻子的解剖结构、肿瘤手术及鼻部缺损修复进行了综述。我们分析了24个月内自己收治的鼻基底细胞癌患者。

结果

我们共确定了321例鼻基底细胞癌患者。女性患者居多,男女比例为1.2比1。平均年龄为74.8岁。所有肿瘤均采用慢速莫氏手术,直至获得三维无瘤切缘。平均进行了1.8±0.7个莫氏手术阶段。最常见的组织学类型为单发性(n = 182)、浸润性(79)和微结节性(20),56例肿瘤可见神经周围浸润。105例基底细胞癌在软组织游离后可行一期缝合。91例肿瘤采用推进皮瓣,47例采用旋转皮瓣,34例采用易位皮瓣,6例采用联合手术。36例患者进行了全厚皮片移植。2例患者选择二期愈合。4例患者(1.4%)出现部分皮瓣坏死。他们均有严重的基础疾病。在观察期内,所有接受治疗的肿瘤均未复发。然而,这是本研究的一个局限性,因为平均随访时间仅为10个月。

结论

鼻基底细胞癌很常见。只有三维控制的显微手术(莫氏或慢速莫氏手术)能保证高肿瘤完全切除率和极低的复发风险。

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