Centers for Disease Control and Prevention, National Center for HIV/Hepatitis/STD/TB Prevention, Division of Viral Hepatitis, Atlanta, GA 30333, USA.
Virus Res. 2011 Oct;161(1):31-9. doi: 10.1016/j.virusres.2011.04.030. Epub 2011 May 11.
Molecular characterization of various hepatitis E virus (HEV) strains circulating among humans and animals (particularly swine, deer and boars) in different countries has revealed substantial genetic heterogeneity. The distinctive four-genotype distribution worldwide of mammalian HEV and varying degrees of genetic relatedness among local strains suggest a long and complex evolution of HEV in different geographic regions. The population expansion likely experienced by mammalian HEV in the second half of the 20th century is consistent with an extensive genetic divergence of HEV strains and high prevalence of HEV infections in many parts of the world, including developed countries. The rate and mechanisms of human-to-human transmission and zoonotic transmission to humans vary geographically, thus contributing to the complexity of HEV molecular evolution.
对不同国家人类和动物（尤其是猪、鹿和野猪）中流行的各种戊型肝炎病毒（HEV）株进行的分子特征分析显示，其存在大量遗传异质性。全球范围内哺乳动物 HEV 独特的四基因型分布以及地方株之间不同程度的遗传相关性表明，HEV 在不同地理区域经历了漫长而复杂的进化过程。哺乳动物 HEV 在 20 世纪后半叶可能经历了种群扩张，这与 HEV 株的广泛遗传分化以及包括发达国家在内的世界许多地区的 HEV 感染高发相一致。人与人之间以及动物向人类的传播速度和机制在地理上有所不同，这导致了 HEV 分子进化的复杂性。
