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在大肠杆菌中合成lichenicidin：lichenicin 的 FGEHI 免疫基因对于抗生素的产生或自我保护并非必需。

Lichenicidin biosynthesis in Escherichia coli: licFGEHI immunity genes are not essential for lantibiotic production or self-protection.

机构信息

Department of Biology and CESAM, University of Aveiro, 3810 Aveiro, Portugal.

出版信息

Appl Environ Microbiol. 2011 Jul;77(14):5023-6. doi: 10.1128/AEM.00270-11. Epub 2011 May 20.

DOI:10.1128/AEM.00270-11
PMID:21602391
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3147384/
Abstract

This study demonstrated, for the first time, that immunity genes licFGEHI are not essential for self-protection and production of the two-component lantibiotic lichenicidin in the Gram-negative heterologous host Escherichia coli BLic5. Additionally, it was experimentally demonstrated that lichenicidin lantibiotics are active against the E. coli imp4213 strain, a mutant strain possessing a permeable outer membrane.

摘要

本研究首次表明，免疫基因 licFGEHI 对于革兰氏阴性异源宿主大肠杆菌 BLic5 中自身保护和双组份类杆菌素 lichenicidin 的产生并非必需。此外，实验证明，lichenicidin 类杆菌素对具有渗透性外膜的突变株 E. coli imp4213 菌株具有活性。

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