Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
Nat Rev Mol Cell Biol. 2011 Jun;12(6):392-8. doi: 10.1038/nrm3120.
Nearly 60 years ago, Alan Turing showed theoretically how two chemical species, termed morphogens, diffusing and reacting with each other can generate spatial patterns. Diffusion plays a crucial part in transporting chemical signals through space to establish the length scale of the pattern. When coupled to chemical reactions, mechanical processes - forces and flows generated by motor proteins - can also define length scales and provide a mechanochemical basis for morphogenesis. forces and flows generated by motor proteins - can also define length scales and provide a mechanochemical basis for morphogenesis.
近 60 年前,艾伦·图灵从理论上展示了两种化学物质——形态发生素——如何通过扩散和相互反应产生空间模式。扩散在通过空间运输化学信号以建立模式的长度尺度方面起着至关重要的作用。当与化学反应结合时,机械过程——由马达蛋白产生的力和流动——也可以定义长度尺度,并为形态发生提供机械化学基础。