Villalta D, Asero R
Allergologia e Immunologia Clinica, Dipartimento di Medicina di Laboratorio, A.O. S. Maria degli Angeli, Pordenone, Italy.
Eur Ann Allergy Clin Immunol. 2011 Mar;43(2):54-7.
The allergenic profile of patients hypersensitive to pollen pan-allergens, profilin and polcalcin, has received little attention so far.
To detect whether hypersensitivity to profilin and polcalcin follows sensitization to specific allergen sources or represents a primary phenomenon, and to examine the sensitization profiles of patients hypersensitive to pollen pan-allergens.
IgE reactivity to markers of primary sensitisation to different pollen species including grass, mugwort, ragweed, pellitory, birch, olive, and cypress was detected in sera from 106 pollen-allergic subjects, 86 sensitised to profilin and 29 to polcalcin living in two distinct areas of Northern Italy.
In profilin hypersensitive patients the primary sensitizer was detected in 24/86 (28%) cases: grass (n=15), ragweed (n=7), and birch (n=2). In 62 (72%) cases the primary sensitizing pollen was not detectable. In the polcalcin group the primary sensitizing pollen was detected in 8/29 (28%) cases: grass (n=6), ragweed and pellitory (1 each). All ragweed-allergic subjects were from the Milan area. In the 9 patients hypersensitive to both panallergens the primary sensitizing source could be identified in 2 (23%) cases (grass in both cases).
A putative primary sensitizer to pollen pan-allergens can be detected only in 1/4 of cases, as most patients show IgE specific for >1 pollen species. In these patients the prevalence of the primary sensitizer parallels the prevalence of clinical allergy to the different pollen sources in that specific geographic area. Most pollen sources are probably able to cause sensitization to cross-reacting pollen pan-allergens.
对花粉泛过敏原、肌动蛋白结合蛋白和钙结合蛋白过敏的患者的过敏原特征，到目前为止很少受到关注。
检测对肌动蛋白结合蛋白和钙结合蛋白的过敏是否继发于对特定过敏原来源的致敏，或是否代表一种原发性现象，并检查对花粉泛过敏原过敏的患者的致敏特征。
在来自意大利北部两个不同地区的106名花粉过敏受试者、86名对肌动蛋白结合蛋白致敏和29名对钙结合蛋白致敏的患者血清中，检测对不同花粉种类（包括禾本科植物、艾蒿、豚草、墙草、桦树、橄榄和柏树）的原发性致敏标志物的IgE反应性。
在对肌动蛋白结合蛋白过敏的患者中，24/86（28%）例检测到原发性致敏原：禾本科植物（n = 15）、豚草（n = 7）和桦树（n = 2）。62（72%）例中未检测到原发性致敏花粉。在钙结合蛋白组中，8/29（28%）例检测到原发性致敏花粉：禾本科植物（n = 6）、豚草和墙草各1例。所有豚草过敏受试者均来自米兰地区。在9名对两种泛过敏原均过敏的患者中，2（23%）例可确定原发性致敏源（两例均为禾本科植物）。
仅在1/4的病例中可检测到假定的花粉泛过敏原原发性致敏原，因为大多数患者显示对>1种花粉种类具有IgE特异性。在这些患者中，原发性致敏原的患病率与该特定地理区域中对不同花粉来源的临床过敏患病率相当。大多数花粉来源可能能够导致对交叉反应性花粉泛过敏原的致敏。
