BMJ. 1990 May 5;300(6733):1166-70. doi: 10.1136/bmj.300.6733.1166.
To determine the fetal infection rate and outcome of pregnancy among women who acquire infection with human parvovirus (B19) in the antenatal period.
Prospective study of infected pregnancies till time of delivery or abortion with virological investigation of fetuses, neonates, and 1 year old infants.
England and Wales during 1985-8.
190 Pregnant women with serologically confirmed B19 infection in pregnancy, their fetuses, neonates, and 1 year old infants.
Of 186 mothers who elected to go to term, 156 (84%) delivered a normal baby. Follow up of 114 of these infants to the age of 1 year disclosed no appreciable abnormalities, although 27 had serological evidence of intrauterine infection. The overall fetal loss rate (30 cases; 16%) was similar to that in an uninfected antenatal sample (unmatched), but there was a pronounced excess of fetal loss in the second trimester in the B19 infected mothers (11.8%; 95% confidence interval 6.8% to 17.8%). Based on virological findings in the aborted fetuses the risk of fetal death due to B19 in an infected pregnancy was estimated to be 9%. The transplacental transmission rate was estimated to be 33%.
Most women with B19 infection in pregnancy had a satisfactory outcome, but there was nevertheless a substantial risk of fetal loss in the second trimester. In view of the absence to date of any evidence of damage to babies who survive maternal infection therapeutic termination of pregnancy is not indicated.
确定孕期感染人细小病毒（B19）的女性的胎儿感染率及妊娠结局。
对感染妊娠进行前瞻性研究直至分娩或流产，并对胎儿、新生儿及1岁婴儿进行病毒学调查。
1985 - 1988年期间的英格兰和威尔士。
190名孕期血清学确诊为B19感染的孕妇及其胎儿、新生儿和1岁婴儿。
186名选择足月分娩的母亲中，156名（84%）产下正常婴儿。对其中114名婴儿随访至1岁，未发现明显异常，尽管有27名婴儿有宫内感染的血清学证据。总体胎儿丢失率（30例；16%）与未感染的产前样本（未匹配）相似，但B19感染母亲在孕中期的胎儿丢失明显过多（11.8%；95%置信区间6.8%至17.8%）。根据流产胎儿的病毒学检查结果，估计感染妊娠中因B19导致胎儿死亡的风险为9%。经胎盘传播率估计为33%。
大多数孕期感染B19的女性妊娠结局良好，但孕中期仍有相当大的胎儿丢失风险。鉴于目前尚无证据表明母体感染后存活的婴儿有损害，不建议进行治疗性引产。
