Department of ENT Head and Neck Surgery, Odense University Hospital, Denmark.
Oral Oncol. 2012 Feb;48(2):179-85. doi: 10.1016/j.oraloncology.2011.09.005. Epub 2011 Oct 2.
To describe outcome and prognostic factors in a national Danish series of patients treated for salivary gland carcinoma. From three Danish nation-wide registries and supplementary patient records, 871 patients diagnosed with primary major or minor salivary gland carcinoma in the period from 1990 to 2005 were identified. A total of 796 (91%) histological specimens were revised according to the WHO 2005 classification. The median follow-up time was 78 months. Three hundred and thirty-four patients (38%) experienced recurrence. Crude survival, disease-specific survival and recurrence-free survival after 5 and 10 years were 66%, 76%, 64% and 51%, 69%, 58%, respectively. In multivariate analysis age, latency, stage, microscopic margins, vascular invasion and histological grade were all independent prognostic factors with regards to crude and disease-specific survival. Stage, microscopic margins, vascular invasion and histological grade were independent prognostic factors for recurrence-free survival. Age over 61 years, latency under 8 months, stage 3+4 disease, involved or close microscopic margins, vascular invasion and high histological grade are all independent prognostic factors with a negative impact on survival in salivary gland carcinoma patients. This knowledge can be helpful in guiding clinicians in daily work and choice of treatment across the large variety of salivary gland carcinoma subtypes.
描述丹麦全国性唾液腺癌患者治疗的结果和预后因素。从三个丹麦全国性登记处和补充的患者记录中，确定了 1990 年至 2005 年期间诊断为原发性主要或次要涎腺癌的 871 名患者。共有 796 例（91%）组织学标本根据 2005 年世界卫生组织分类进行了修订。中位随访时间为 78 个月。334 例（38%）患者复发。5 年和 10 年后的粗生存率、疾病特异性生存率和无复发生存率分别为 66%、76%、64%和 51%、69%、58%。多变量分析显示，年龄、潜伏期、分期、显微镜下边缘、血管侵犯和组织学分级均为粗生存率和疾病特异性生存率的独立预后因素。分期、显微镜下边缘、血管侵犯和组织学分级是无复发生存率的独立预后因素。年龄>61 岁、潜伏期<8 个月、分期 3+4 期、受累或接近显微镜下边缘、血管侵犯和高组织学分级是所有独立的预后因素，对唾液腺癌患者的生存有负面影响。这些知识有助于指导临床医生在日常工作中根据各种唾液腺癌亚型选择治疗方法。
