Hopitaux Universitaires de Strasbourg, Pole de Cardiologie et de chirurgie cardiovasculaire, Strasbourg, France.
Front Biosci (Landmark Ed). 2011 Jun 1;16(7):2499-514. doi: 10.2741/3868.
Microparticles (MPs) are submicron vesicles released from stimulated or apoptotic cells after plasma membrane remodeling. In body fluids, they constitute relevant hallmarks of cell damage. Having long been considered inert debris reflecting cellular activation or damage, MPs are now considered as cellular effectors involved in cell-cell crosstalk. This review focuses on the pathophysiologic significance of MPs in the particular setting of solid graft and cellular transplantation.
微粒（MPs）是细胞膜重塑后由受刺激或凋亡细胞释放的亚微米囊泡。在体液中，它们构成了细胞损伤的相关特征。长期以来，MPs 一直被认为是反映细胞激活或损伤的无活性碎片，但现在被认为是参与细胞间通讯的细胞效应器。这篇综述主要关注 MPs 在实体移植物和细胞移植特定环境中的病理生理意义。
