Lee Seung Jun, Jung Min Kyu, Kim Sung Kook, Jang Byung Ik, Lee Si Hyung, Kim Kyeong Ok, Kim Eun Soo, Cho Kwang Bum, Park Kyung Sik, Kim Eun Young, Jung Jin Tae, Kwon Joong Goo, Lee Joong Hyun, Yang Chang Hun, Park Chang Keun, Seo Hyang Eun, Jeon Seong Woo
Department of Internal Medicine, Kyungpook National University School of Medicine, Korea.
Korean J Gastroenterol. 2011 May 25;57(5):281-7. doi: 10.4166/kjg.2011.57.5.281.
BACKGROUND/AIMS: Recent studies suggest that the prevalence of gastroesophageal reflux disease (GERD) is increasing in Korea. However, studies on risk factors for GERD have yielded inconsistent results. The aims of this study were to compare clinical features between symptomatic syndromes without esophageal injury (=non-erosive disease [NED]) and syndromes with esophageal injury (=erosive disease [ED]), and to determine risk factors associated ED.
A total of 450 subjects who visited gastroenterology clinics of six training hospitals in Daegu from March 2008 to April 2010 were consecutively enrolled. The subjects were asked to complete a questionnaire which inquired about gastroesophageal reflux symptoms. The questionnaire also included questions about smoking, alcohol drinking, consumption of coffee, use of drugs, exercise, and other medical history. The subjects were subdivided into NED and ED groups.
The proportion of subjects in each NED and ED group was 172 (38.2%) and 278 (61.8%). Male gender, smoking, alcohol drinking, consumption of coffee, large waist circumference, infrequent medication of antacids, aspirin and NSAIDs, infrequent and mild GERD symptoms were all significantly associated with ED on univariate analysis. Age, hiatal hernia, diabetes mellitus, body mass index, change in weight during 1 year, and number of typical GERD symptoms were not independent risk factors for ED. However, the association between ED and alcohol drinking, infrequent medication of antacids, mild typical GERD symptoms remained as strong risk factors after adjustments on multivariate logistic analysis.
Independent risk factors associated with ED were alcohol drinking, infrequent medication of antacids and mild typical GERD symptoms.
背景/目的：近期研究表明，韩国胃食管反流病（GERD）的患病率正在上升。然而，关于GERD危险因素的研究结果并不一致。本研究的目的是比较无食管损伤的症状综合征（=非糜烂性疾病[NED]）和有食管损伤的症状综合征（=糜烂性疾病[ED]）的临床特征，并确定与ED相关的危险因素。
2008年3月至2010年4月期间，连续纳入了大邱市六家教学医院胃肠病科就诊的450名受试者。要求受试者完成一份关于胃食管反流症状的问卷。该问卷还包括有关吸烟、饮酒、咖啡消费、药物使用、运动及其他病史的问题。受试者被分为NED组和ED组。
NED组和ED组的受试者比例分别为172名（38.2%）和278名（61.8%）。单因素分析显示，男性、吸烟、饮酒、咖啡消费、腰围大、抗酸剂、阿司匹林和非甾体抗炎药用药频率低、GERD症状不频繁及症状轻微均与ED显著相关。年龄、食管裂孔疝、糖尿病、体重指数、1年内体重变化及典型GERD症状数量不是ED的独立危险因素。然而，在多因素逻辑分析调整后，饮酒、抗酸剂用药频率低、典型GERD症状轻微与ED之间的关联仍然是强烈的危险因素。
与ED相关的独立危险因素是饮酒、抗酸剂用药频率低和典型GERD症状轻微。
