J Biol Rhythms. 2011 Jun;26(3):276-9. doi: 10.1177/0748730411402026.
Genetic association studies of the CLOCK 3111C/T polymorphism and diurnal preference have yielded conflicting results since the first report that the 3111C allele was associated with eveningness. The goal of the present study was to investigate the association of this polymorphism with diurnal preference and circadian physiology in a group of 179 individuals, by comparing the frequency of the 3111C allele to diurnal preference, habitual sleep timing, circadian phase markers, and circadian period. We did not find a significant association between this allele and morningness/eveningness or any circadian marker.
关于 CLOCK 3111C/T 多态性与昼夜倾向的遗传关联研究，自首次报道 3111C 等位基因与夜间型相关以来，结果一直存在争议。本研究的目的是通过比较 3111C 等位基因的频率与昼夜倾向、习惯性睡眠时间、昼夜节律标记物和昼夜节律周期，在 179 名个体中研究该多态性与昼夜倾向和生物钟生理学之间的关系。我们没有发现该等位基因与晨型/晚型或任何生物钟标记物之间存在显著关联。
