Fichtali Karima, Bititi Amine, Elghanmi Adil, Ghazi Bouchra
Cheikh Khalifa International Hospital, Faculty of Medicine, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.
National Laboratory of Reference, Faculty of Medicine, Mohammed VI University of Health Sciences (UM6SS), Casablanca, Morocco.
Biores Open Access. 2020 Jan 3;9(1):1-6. doi: 10.1089/biores.2018.0022. eCollection 2020.
Breast cancer is the major mortality cause of women worldwide. In the course of management of breast cancer, the identification of a biomarker is important in enhancing our knowledge on cancer pathology, predicting the response to treatment, and selecting the patients who are more favorable to receive certain treatments. These biomarkers have a prognostic value. In addition to traditional breast cancer prognosis factors such as the tumor size and grade, the axillary lymph node micrometastasis, and biomarkers such as HER2/neu, newly discovered biomarkers have been discovered. Some of these factors are genetic signature in tissue or in peripheral blood. Lipid profil, a simple and accessible biological examination, has been a novel path on the prediction of breast cancer risk of occurrence and recurrence in many studies. The main goal of our review is to evaluate lipid profile and breast cancer risk with an emphasis on the prognosis value of lipid profiles in breast cancer patient management.
乳腺癌是全球女性的主要死因。在乳腺癌的治疗过程中，生物标志物的识别对于增进我们对癌症病理学的了解、预测治疗反应以及选择更适合接受某些治疗的患者至关重要。这些生物标志物具有预后价值。除了传统的乳腺癌预后因素，如肿瘤大小和分级、腋窝淋巴结微转移以及HER2/neu等生物标志物外，还发现了一些新的生物标志物。其中一些因素是组织或外周血中的基因特征。血脂谱，一种简单且可及的生物学检查，在许多研究中已成为预测乳腺癌发生和复发风险的新途径。我们综述的主要目的是评估血脂谱与乳腺癌风险，重点关注血脂谱在乳腺癌患者管理中的预后价值。
