Department of Gastroenterology, St Vincent's Hospital, 390 Victoria Street, Darlinghurst, 2010 NSW, Australia.
World J Gastroenterol. 2011 May 21;17(19):2365-71. doi: 10.3748/wjg.v17.i19.2365.
Pancreatic cancer is difficult to diagnose at an early stage and is associated with a very poor survival. Ten percent of pancreatic cancers result from genetic susceptibility and/or familial aggregation. Individuals from families with multiple affected first-degree relatives and those with a known cancer-causing genetic mutation have been shown to be at much higher risk of developing pancreatic cancer. Recent efforts have focused on detecting disease at an earlier stage to improve survival in these high-risk groups. This article reviews high-risk groups, screening methods, and current screening programs and their results.
胰腺癌在早期阶段难以诊断，且患者的生存率非常低。有 10%的胰腺癌是由遗传易感性和/或家族聚集引起的。有多个一级亲属受影响的家族成员，以及携带已知致癌基因突变的个体，其患胰腺癌的风险要高得多。最近的研究重点是在这些高危人群中更早地发现疾病，以提高生存率。本文回顾了高危人群、筛查方法、以及当前的筛查计划及其结果。
