系统性红斑狼疮中B细胞功能缺陷
Defective B cell function in systemic lupus erythematosus.
作者信息
Pelton B K, Denman A M
出版信息
Clin Exp Immunol. 1982 Jun;48(3):513-8.
Abstract
The in vitro synthesis of specific anti-influenza virus antibody was measured in cultures of peripheral blood lymphocytes from 25 patients with systemic lupus erythematosus (SLE) and 23 control subjects. Whilst all cultures derived from normal individuals synthesized specific antibody, cultures from patients with SLE were consistently unable to produce anti-influenza antibody. This defect could not be corrected by manipulating the culture conditions or by in vivo immunization. Co-cultivation of separated SLE-B or control B cells, with SLE-T or control T cells showed that the immunodeficiency exhibited by the SLE peripheral blood lymphocytes resides in the B cells.
摘要
对25例系统性红斑狼疮（SLE）患者和23名对照者的外周血淋巴细胞培养物进行检测，以测定特异性抗流感病毒抗体的体外合成情况。虽然所有来自正常个体的培养物都能合成特异性抗体，但SLE患者的培养物始终无法产生抗流感抗体。通过改变培养条件或进行体内免疫，均无法纠正这一缺陷。将分离出的SLE-B细胞或对照B细胞与SLE-T细胞或对照T细胞共同培养，结果显示SLE外周血淋巴细胞所表现出的免疫缺陷存在于B细胞中。
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