University of California, Los Angeles, Center for Advanced Surgical and Interventional Technology, Los Angeles, California 90095, USA.
J Biomed Opt. 2011 May;16(5):057003. doi: 10.1117/1.3575168.
This work introduces the potential application of terahertz (THz) sensing to the field of ophthalmology, where it is uniquely suited due to its nonionizing photon energy and high sensitivity to water content. Reflective THz imaging and spectrometry data are reported on ex-vivo porcine corneas prepared with uniform water concentrations using polyethylene glycol (PEG) solutions. At 79% water concentration by mass, the measured reflectivity of the cornea was 20.4%, 14.7%, 11.7%, 9.6%, and 7.4% at 0.2, 0.4, 0.6, 0.8, and 1 THz, respectively. Comparison of nine corneas hydrated from 79.1% to 91.5% concentration by mass demonstrated an approximately linear relationship between THz reflectivity and water concentration, with a monotonically decreasing slope as the frequency increases. The THz-corneal tissue interaction is simulated with a Bruggeman model with excellent agreement. THz applications to corneal dystrophy, graft rejection, and refractive surgery are examined from the context of these measurements.
这项工作介绍了太赫兹（THz）传感在眼科领域的潜在应用，由于其非电离光子能量和对水含量的高灵敏度，THz 传感在该领域具有独特的适用性。使用聚乙二醇（PEG）溶液制备具有均匀水浓度的离体猪角膜，报告了反射 THz 成像和光谱数据。在质量分数为 79%的水浓度下，角膜在 0.2、0.4、0.6、0.8 和 1 THz 处的测量反射率分别为 20.4%、14.7%、11.7%、9.6%和 7.4%。比较了 9 只从 79.1%到 91.5%质量分数水合的角膜，结果表明 THz 反射率与水浓度之间存在近似线性关系，随着频率的增加，斜率单调下降。THz 与角膜组织的相互作用用 Bruggeman 模型进行了模拟，模拟结果非常吻合。从这些测量结果出发，探讨了 THz 在角膜营养不良、移植物排斥和屈光手术中的应用。
