Ostrander Serena, Cazares Victor A, Kim Charissa, Cheung Shauna, Gonzalez Isabel, Izquierdo Alicia
Laboratory of Cognitive Neuroscience, Department of Psychology, California State University, Los Angeles, 5151 State University Drive, Los Angeles, CA 90032, USA.
Behav Neurosci. 2011 Jun;125(3):350-9. doi: 10.1037/a0023574.
The orbitofrontal cortex (OFC) and basolateral nucleus of the amygdala (BLA) are important neural regions in responding adaptively to changes in the incentive value of reward. Recent evidence suggests these structures may be differentially engaged in effort and cue-guided choice behavior. In 2 T-maze experiments, we examined the effects of bilateral lesions of either BLA or OFC on (1) effortful choices in which rats could climb a barrier for a high reward or select a low reward with no effort and (2) effortful choices when a visual cue signaled changes in reward magnitude. In both experiments, BLA rats displayed transient work aversion, choosing the effortless low reward option. OFC rats were work averse only in the no cue conditions, displaying a pattern of attenuated recovery from the cue conditions signaling reward unavailability in the effortful arm. Control measures rule out an inability to discriminate the cue in either lesion group.
眶额皮质（OFC）和杏仁核基底外侧核（BLA）是对奖励激励价值变化进行适应性反应的重要神经区域。最近的证据表明，这些结构在努力和线索引导的选择行为中可能有不同的参与。在两项T迷宫实验中，我们研究了双侧损毁BLA或OFC对以下方面的影响：（1）大鼠可以攀爬障碍物以获得高奖励或不费力地选择低奖励的努力选择；（2）当视觉线索表明奖励大小发生变化时的努力选择。在两项实验中，损毁BLA的大鼠表现出短暂的工作厌恶，选择不费力的低奖励选项。损毁OFC的大鼠仅在无线索条件下表现出工作厌恶，在提示努力臂中奖励不可用的线索条件下，恢复减弱。对照措施排除了任一损毁组无法辨别线索的可能性。
