Chelu Mariana, Popa Monica, Calderon Moreno Jose, Leonties Anca Ruxandra, Ozon Emma Adriana, Pandele Cusu Jeanina, Surdu Vasile Adrian, Aricov Ludmila, Musuc Adina Magdalena
"Ilie Murgulescu" Institute of Physical Chemistry, 202 Spl. Independentei, 060021 Bucharest, Romania.
Department of Pharmaceutical Technology and Biopharmacy, Faculty of Pharmacy, Carol Davila University of Medicine and Pharmacy, 6 Traian Vuia Street, 020945 Bucharest, Romania.
Gels. 2023 Jun 1;9(6):454. doi: 10.3390/gels9060454.
The removal of pharmaceutical contaminants from wastewater has gained considerable attention in recent years, particularly in the advancements of hydrogel-based adsorbents as a green solution for their ease of use, ease of modification, biodegradability, non-toxicity, environmental friendliness, and cost-effectiveness. This study focuses on the design of an efficient adsorbent hydrogel based on 1% chitosan, 40% polyethylene glycol 4000 (PEG4000), and 4% xanthan gum (referred to as CPX) for the removal of diclofenac sodium (DCF) from water. The interaction between positively charged chitosan and negatively charged xanthan gum and PEG4000 leads to strengthening of the hydrogel structure. The obtained CPX hydrogel, prepared by a green, simple, easy, low-cost, and ecological method, has a higher viscosity due to the three-dimensional polymer network and mechanical stability. The physical, chemical, rheological, and pharmacotechnical parameters of the synthesized hydrogel were determined. Swelling analysis demonstrated that the new synthetized hydrogel is not pH-dependent. The obtained adsorbent hydrogel reached the adsorption capacity (172.41 mg/g) at the highest adsorbent amount (200 mg) after 350 min. In addition, the adsorption kinetics were calculated using a pseudo first-order model and Langmuir and Freundlich isotherm parameters. The results demonstrate that CPX hydrogel can be used as an efficient option to remove DCF as a pharmaceutical contaminant from wastewater.
近年来，从废水中去除药物污染物受到了广泛关注，特别是基于水凝胶的吸附剂取得了显著进展，它作为一种绿色解决方案，具有使用方便、易于改性、可生物降解、无毒、环保和成本效益高等优点。本研究聚焦于设计一种高效的吸附性水凝胶，其由1%的壳聚糖、40%的聚乙二醇4000（PEG4000）和4%的黄原胶（称为CPX）组成，用于从水中去除双氯芬酸钠（DCF）。带正电荷的壳聚糖与带负电荷的黄原胶和PEG4000之间的相互作用导致水凝胶结构得到强化。通过绿色、简单、易行、低成本且生态的方法制备的CPX水凝胶，由于其三维聚合物网络而具有较高的粘度和机械稳定性。测定了合成水凝胶的物理、化学、流变学和药学技术参数。溶胀分析表明，新合成的水凝胶不依赖于pH值。在350分钟后，当吸附剂用量最高为200毫克时，所获得的吸附性水凝胶达到了吸附容量（172.41毫克/克）。此外，使用伪一级模型以及朗缪尔和弗伦德利希等温线参数计算了吸附动力学。结果表明，CPX水凝胶可作为一种高效的选择，用于从废水中去除作为药物污染物的DCF。
