Takahashi T, Imai K, Sugiyama T, Kodama T, Osato T, Imai S, Mizuno F, Yamada K, Mochizuki Y, Yachi A
1st Dept. of Int. Med., Sapporo Medical College.
Gan No Rinsho. 1990 Jul;36(8):914-8.
An 83-year-old man suffering from general malaise and discomfort in the epigastrium was admitted to hospital. On testing, peripheral blood and bone marrow smears disclosed a number of abnormal lymphocytoid cells, and a CT and a linear echo scan revealed splenomegaly and a multiple intraperitoneal lymphadenopathy, although no superficial lymph nodes were palpable. Further, abnormal lymphocytoid cells were positive for B1, B4, OKIa1, Leu1, Tac, anti-IgM, anti-IgD, and anti-lambda. Thus, a diagnosis of malignant lymphoma of the intermediate B-cell type was made. Surprisingly, serological examination reveared extremely high titers of EB-virus associated antibodies (VCAIgG 20, 480x, VCAIgA 320x, EAIgG 2,560x), but no EBNA or virus particles were detected in the tumor cells, so that no direct relationship was established between the development of the tumor and the EBV infection.
一名83岁男性因全身不适和上腹部不适入院。检查发现，外周血和骨髓涂片中有许多异常淋巴细胞样细胞，CT和线性超声扫描显示脾肿大和多处腹腔内淋巴结肿大，尽管未触及浅表淋巴结。此外，异常淋巴细胞样细胞对B1、B4、OKIa1、Leu1、Tac、抗IgM、抗IgD和抗λ呈阳性。因此，诊断为中间B细胞型恶性淋巴瘤。令人惊讶的是，血清学检查显示EB病毒相关抗体滴度极高（VCAIgG 20480倍、VCAIgA 320倍、EAIgG 2560倍），但在肿瘤细胞中未检测到EBNA或病毒颗粒，因此肿瘤的发生与EBV感染之间未建立直接关系。
