肾脏神经、WNK4、糖皮质激素和盐转运。
Renal nerves, WNK4, glucocorticoids, and salt transport.
机构信息
Division of Nephrology and Hypertension, Oregon Health and Science University, Portland, OR 97239, USA.
出版信息
Cell Metab. 2011 Jun 8;13(6):619-20. doi: 10.1016/j.cmet.2011.05.007.
Abstract
Roles of the sympathetic nervous system versus kidney salt transporters in hypertension are debated. A study in Nature Medicine (Mu et al., 2011) shows that dietary salt excess, coupled with β-adrenergic stimulation, increases arterial pressure via glucocorticoid receptors and WNK4, suggesting interactions between these systems in the pathogenesis of hypertension.
摘要
交感神经系统与肾脏盐转运体在高血压中的作用存在争议。《自然医学》（Mu 等人，2011 年）的一项研究表明，饮食盐过量加上β肾上腺素刺激，通过糖皮质激素受体和 WNK4 增加动脉血压，提示这些系统在高血压发病机制中的相互作用。
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