Associazione Ginecologi Unfer Costabile (AGUNCO) Obstetrics and Gynecology Center, Rome, Italy.
Fertil Steril. 2011 Jun 30;95(8):2515-6. doi: 10.1016/j.fertnstert.2011.05.027. Epub 2011 Jun 8.
The D-chiro-inositol-to-myo-inositol ratio is regulated by an insulin-dependent epimerase. Enzyme activity varies among tissues, likely owing to the specific needs of the two different molecules. We hypothesize that in the ovaries of polycystic ovary syndrome patients, epimerase activity is enhanced, leading to a local myo-inositol deficiency which in turn is responsible for the poor oocyte quality.
D-手性肌醇与肌醇的比例受胰岛素依赖的差向异构酶调控。由于两种不同分子的特殊需求，酶活性在不同组织中存在差异。我们假设，在多囊卵巢综合征患者的卵巢中，差向异构酶活性增强，导致局部肌醇缺乏，进而导致卵子质量差。
