Department of Nephrology, Kasr El-Aini School of Medicine, Cairo University, Cairo, Egypt.
Int Urol Nephrol. 2012 Aug;44(4):1193-9. doi: 10.1007/s11255-011-0007-x. Epub 2011 Jun 4.
Advanced glycation end-products (AGE) accumulate in CKD and may predispose to cardiovascular disease by inducing inflammatory and oxidant stress in the vascular endothelium. Soluble forms of the receptor for AGE (RAGE) may be protective against these effects by binding AGE in the soluble phase. Accumulating evidence suggests a protective role of soluble RAGE against vascular calcification. This study investigates the association between endogenous soluble RAGE (esRAGE) and vascular calcification in hemodialysis patients.
We studied 65 non-diabetic hemodialysis patients, on 3 × 4 h dialysis schedule, and 19 controls. Serum levels of esRAGE, hsCRP, parathormone, lipids, calcium, and phosphorus were measured. Aortic calcification index (ACI) was measured using non-contrast CT of the abdominal aorta.
Aortic calcification was detected in 64 out of 65 hemodialysis patients. Levels of esRAGE were lower in hemodialysis patients (278 pg/ml, SD 101.1) than in controls (443 ± 109 pg/ml; P = 0.001). ACI correlated negatively in stepwise multivariate analysis with esRAGE (P = 0.002) and positively with hsCRP (<0.0001), systolic blood pressure (P < 0.0001) and dialysis vintage (P = 0.05); R (2) = 0.65.
Levels of esRAGE were low among hemodialysis patients and correlated negatively with ACI.
晚期糖基化终末产物（AGE）在 CKD 中蓄积，通过在血管内皮诱导炎症和氧化应激，可能使心血管疾病易于发生。AGE 的可溶性受体（RAGE）的可溶性形式可以通过在可溶性相中结合 AGE 而起到保护作用。越来越多的证据表明可溶性 RAGE（esRAGE）对血管钙化具有保护作用。本研究调查了内源性可溶性 RAGE（esRAGE）与血液透析患者血管钙化之间的关系。
我们研究了 65 名非糖尿病血液透析患者，他们接受 3×4 小时透析方案，以及 19 名对照者。测量血清 esRAGE、hsCRP、甲状旁腺激素、脂质、钙和磷的水平。使用腹部主动脉非对比 CT 测量主动脉钙化指数（ACI）。
在 65 名血液透析患者中，有 64 名患者检测到主动脉钙化。血液透析患者的 esRAGE 水平低于对照组（278pg/ml，SD 101.1）（443±109pg/ml；P=0.001）。逐步多元分析显示，ACI 与 esRAGE 呈负相关（P=0.002），与 hsCRP（<0.0001）、收缩压（P<0.0001）和透析年限（P=0.05）呈正相关；R（2）=0.65。
血液透析患者的 esRAGE 水平较低，与 ACI 呈负相关。
