Department of Chemistry, Brown University, Providence, Rhode Island 02912, United States.
Nano Lett. 2011 Jul 13;11(7):2678-83. doi: 10.1021/nl200858y. Epub 2011 Jun 6.
We present the development of a new imaging technique for the early diagnosis of hepatocellular carcinoma that utilizes surface-modified gold nanoparticles in combination with X-ray imaging. Tissues labeled with these electron-dense particles show enhanced X-ray scattering over normal tissues, distinguishing cells containing gold nanoparticles from cells without gold in X-ray scatter images. Our results suggest that this novel approach could enable the in vivo detection of tumors as small as a few millimeters in size.
我们提出了一种新的成像技术，用于早期诊断肝细胞癌，该技术结合了表面修饰的金纳米粒子和 X 射线成像。用这些电子致密粒子标记的组织在 X 射线散射图像中表现出比正常组织更高的 X 射线散射，从而可以将含有金纳米粒子的细胞与不含金的细胞区分开来。我们的结果表明，这种新方法可以实现对几毫米大小的肿瘤的体内检测。
