Koike K, Jay G, Hartley J W, Schrenzel M D, Higgins R J, Hinrichs S H
Laboratory of Virology, Jerome H. Holland Laboratory, American Red Cross, Rockville, Maryland 20855.
J Virol. 1990 Aug;64(8):3988-91. doi: 10.1128/JVI.64.8.3988-3991.1990.
A line of transgenic mice that express the human adenovirus type 12 E1A and E1B genes under the regulatory control of the mouse mammary tumor virus long terminal repeat was studied. Mice from this line develop olfactory neuroblastomas at approximately 6 months of age. Large numbers of type C retrovirus (ecotropic murine leukemia virus) particles were found in the tumor rosettes. No similar examples of virus activation were identified in tumors from other transgenic experiments. Examination of spontaneous olfactory neuroblastomas from three domestic cats also demonstrated retrovirus in tumor rosettes.
对一组转基因小鼠进行了研究，这些小鼠在小鼠乳腺肿瘤病毒长末端重复序列的调控下表达人12型腺病毒E1A和E1B基因。该品系的小鼠在大约6个月大时会发生嗅神经母细胞瘤。在肿瘤玫瑰花结中发现了大量C型逆转录病毒（亲嗜性鼠白血病病毒）颗粒。在其他转基因实验的肿瘤中未发现类似的病毒激活例子。对三只家猫的自发性嗅神经母细胞瘤进行检查，也在肿瘤玫瑰花结中发现了逆转录病毒。
