高功能自闭症谱系障碍患者的血浆细胞因子谱。
Plasma cytokine profiles in subjects with high-functioning autism spectrum disorders.
机构信息
Research Center for Child Mental Development, Hamamatsu University School of Medicine, Hamamatsu, Japan.
出版信息
PLoS One. 2011;6(5):e20470. doi: 10.1371/journal.pone.0020470. Epub 2011 May 27.
BACKGROUND
Accumulating evidence suggests that dysregulation of the immune system is involved in the pathophysiology of autism spectrum disorders (ASD). The aim of the study was to explore immunological markers in peripheral plasma samples from non-medicated subjects with high-functioning ASD.
METHODOLOGY/PRINCIPAL FINDINGS: A multiplex assay for cytokines and chemokines was applied to plasma samples from male subjects with high-functioning ASD (n = 28) and matched controls (n = 28). Among a total of 48 analytes examined, the plasma concentrations of IL-1β, IL-1RA, IL-5, IL-8, IL-12(p70), IL-13, IL-17 and GRO-α were significantly higher in subjects with ASD compared with the corresponding values of matched controls after correction for multiple comparisons.
CONCLUSION/SIGNIFICANCE: The results suggest that abnormal immune responses as assessed by multiplex analysis of cytokines may serve as one of the biological trait markers for ASD.
背景
越来越多的证据表明，免疫系统失调与自闭症谱系障碍（ASD）的病理生理学有关。本研究旨在探索免疫标记物在非药物治疗的高功能 ASD 患者外周血浆样本中的作用。
方法/主要发现：采用细胞因子和趋化因子的多重分析方法检测了 28 名高功能 ASD 男性患者和 28 名匹配对照者的血浆样本。在总共检测的 48 种分析物中，经多重比较校正后，ASD 患者的血浆 IL-1β、IL-1RA、IL-5、IL-8、IL-12(p70)、IL-13、IL-17 和 GRO-α 浓度明显高于相应的匹配对照者。
结论/意义：研究结果表明，通过细胞因子的多重分析评估异常免疫反应，可能成为 ASD 的生物特征标记物之一。
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