米曲霉 BCRC 38093 中四个新的吡啶生物碱——米曲霉尼古丁 A-D

Monasnicotinates A-D, four new pyridine alkaloids from the fungal strain Monascus pilosus BCRC 38093.

机构信息

Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI), Hsinchu 300, Taiwan.

出版信息

Molecules. 2011 Jun 7;16(6):4719-27. doi: 10.3390/molecules16064719.

DOI:10.3390/molecules16064719

PMID:21654578

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6264138/

Abstract

Four new pyridine derivatives, monasnicotinates A-D (1-4) were isolated from the red yeast rice of Monascus pilosus BCRC 38093. Their structures were elucidated on the basis of physicochemical evidence, in-depth NMR spectroscopic analysis, and high-resolution mass spectrometry. Their inhibitory effects on NO production was also evaluated.

摘要

从红曲霉菌 Monascus pilosus BCRC 38093 中分离得到四个新的吡啶衍生物，单硝酸烟酸酯 A-D（1-4）。根据理化证据、深入的 NMR 波谱分析和高分辨率质谱分析，确定了它们的结构。还评估了它们对 NO 产生的抑制作用。