膝关节置换术后静脉血栓栓塞症的药物预防与治疗
Pharmacologic prophylaxis and treatment of venous thromboembolism after knee arthroplasty.
作者信息
Shawabkeh Jamal S, Ghnaimat Malek M, Hijazi Ammar M
机构信息
Orthopedic Department, Royal Jordanian Medical Services, P O Box 517, Amman 11118, Jordan.
出版信息
Sultan Qaboos Univ Med J. 2007 Apr;7(1):47-50.
OBJECTIVE
The objective of this study was to evaluate the efficacy of unfractionated heparin, warfarin and low molecular weight heparins (LMWH) used for the prevention of venous thromboembolism in arthroplastic surgery of the knee joint.
METHODS
In this prospective study from August 2002 to November 2004, 60 patients were included and divided into three groups with equal numbers, with each group receiving different treatment protocol. Postoperatively, the occurrence of symptomatic deep vein thrombosis (DVT) or pulmonary embolism (PE) was recorded during the first 30 days after surgery and at a routine follow-up visit.
RESULTS
A significantly lower prevalence of DVT and PE was found in patients using warfarin and LMWH as prophylaxis in comparison with patients using unfractionated heparin.
CONCLUSION
Warfarin and low molecular weight heparins are more beneficial and effective than unfractionated heparin for DVT and PE prophylaxis in arthroplastic knee surgeries.
目的
本研究的目的是评估普通肝素、华法林和低分子量肝素（LMWH）在膝关节置换手术中预防静脉血栓栓塞的疗效。
方法
在这项从2002年8月至2004年11月的前瞻性研究中，纳入了60例患者并将其平均分为三组，每组接受不同的治疗方案。术后，记录术后前30天及常规随访期间有症状的深静脉血栓形成（DVT）或肺栓塞（PE）的发生情况。
结果
与使用普通肝素的患者相比，使用华法林和LMWH进行预防的患者中DVT和PE的患病率显著降低。
结论
在膝关节置换手术中预防DVT和PE方面，华法林和低分子量肝素比普通肝素更有益且有效。
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