Shin Hyun Jin, Cho Byung Joo
Department of Ophthalmology, Konkuk University School of Medicine, Seoul, Korea.
Korean J Ophthalmol. 2011 Jun;25(3):166-73. doi: 10.3341/kjo.2011.25.3.166. Epub 2011 May 24.
To compare the peripapillary retinal nerve fiber layer (RNFL) thickness of normal patients and those with various glaucoma diseases by time domain (Stratus) and spectral domain (Spectralis) optical coherence tomography (OCT).
The RNFL thickness as measured by the Stratus and Spectral OCT was compared (paired t-test). The relationship and agreement of RNFL thickness between the two OCT modalities were evaluated by Pearson correlation, Bland-Altman plot, and area under the receiver operating characteristic curve.
Two-hundred seventeen eyes of 217 patients, including twenty-four normal eyes, ninety-one glaucoma suspects, seventy-six normal tension glaucoma cases, and twenty-six primary open angle glaucoma cases (POAG) were analyzed. The peripapillary RNFL thicknesses as measured by Stratus OCT were significantly greater than those measured by Spectralis OCT. However, in quadrant comparisons, the temporal RNFL thickness obtained using Stratus OCT were significantly less than those obtained using Spectralis OCT. Correlations between RNFL parameters were strong (Pearson correlation coefficient for mean RNFL thickness = 0.88); a high degree of correlation was found in the POAG group. Bland-Altman plotting demonstrated that agreement in the temporal quadrant was greater than any other quadrant.
Both OCT systems were highly correlated and demonstrated strong agreement. However, absolute measurements of peripapillary RNFL thickness differed between Stratus OCT and Spectralis OCT. Thus, measurements with these instruments should not be considered interchangeable. The temporal quadrant was the only sector where RNFL thickness as measured by Spectralis OCT was greater than by Stratus OCT; this demonstrated greater agreement than other sectors.
通过时域（Stratus）和频域（Spectralis）光学相干断层扫描（OCT）比较正常患者与患有各种青光眼疾病患者的视乳头周围视网膜神经纤维层（RNFL）厚度。
比较Stratus和Spectral OCT测量的RNFL厚度（配对t检验）。通过Pearson相关性、Bland-Altman图和受试者操作特征曲线下面积评估两种OCT模式之间RNFL厚度的关系和一致性。
分析了217例患者的217只眼，包括24只正常眼、91只青光眼疑似病例、76只正常眼压性青光眼病例和26只原发性开角型青光眼病例（POAG）。Stratus OCT测量的视乳头周围RNFL厚度显著大于Spectralis OCT测量的厚度。然而，在象限比较中，Stratus OCT获得的颞侧RNFL厚度显著小于Spectralis OCT获得的厚度。RNFL参数之间的相关性很强（平均RNFL厚度的Pearson相关系数 = 0.88）；在POAG组中发现高度相关性。Bland-Altman图显示颞侧象限的一致性大于其他任何象限。
两种OCT系统高度相关且显示出很强的一致性。然而，Stratus OCT和Spectralis OCT对视乳头周围RNFL厚度的绝对测量值不同。因此，不应认为使用这些仪器进行的测量是可互换的。颞侧象限是Spectralis OCT测量的RNFL厚度大于Stratus OCT测量厚度的唯一象限；这表明该象限的一致性高于其他象限。
