Barkhordarian André, Ajaj Reem, Ramchandani Manisha H, Demerjian Gary, Cayabyab Riana, Danaie Sohrab, Ghodousi Nora, Iyer Natasha, Mahanian Nicole, Phi Linda, Giroux Amy, Manfrini Ercolano, Neagos Negoita, Siddiqui Muniza, Cajulis Olivia S, Brant Xenia M C, Shapshak Paul, Chiappelli Francesco
Section of Oral Biology, Division of Oral Biology & Medicine, UCLA School of Dentistry, Los Angeles, CA 90095, USA.
Patholog Res Int. 2011;2011:359242. doi: 10.4061/2011/359242. Epub 2011 May 21.
Infection with the human immunodeficiency virus-1 (HIV) and the resulting acquired immune deficiency syndrome (AIDS) alter not only cellular immune regulation but also the bone metabolism. Since cellular immunity and bone metabolism are intimately intertwined in the osteoimmune network, it is to be expected that bone metabolism is also affected in patients with HIV/AIDS. The concerted evidence points convincingly toward impaired activity of osteoblasts and increased activity of osteoclasts in patients with HIV/AIDS, leading to a significant increase in the prevalence of osteoporosis. Research attributes these outcomes in part at least to the ART, PI, and HAART therapies endured by these patients. We review and discuss these lines of evidence from the perspective of translational clinically relevant complex systematic reviews for comparative effectiveness analysis and evidence-based intervention on a global scale.
感染人类免疫缺陷病毒1型（HIV）及由此导致的获得性免疫缺陷综合征（AIDS）不仅会改变细胞免疫调节，还会影响骨代谢。由于在骨免疫网络中细胞免疫与骨代谢紧密相连，因此可以预期HIV/AIDS患者的骨代谢也会受到影响。确凿的证据令人信服地表明，HIV/AIDS患者成骨细胞活性受损，破骨细胞活性增加，导致骨质疏松患病率显著上升。研究认为，这些结果至少部分归因于这些患者所接受的抗逆转录病毒治疗（ART）、蛋白酶抑制剂（PI）和高效抗逆转录病毒治疗（HAART）。我们从转化临床相关复杂系统评价的角度对这些证据进行综述和讨论，以便在全球范围内进行比较有效性分析和基于证据的干预。
