Laboratory of Cell & Molecular Biology, Institute of Vegetable Science, Zhejiang University, Hangzhou, China.
Hangzhou Xiaoshan District Agricultural Technology Extension Center, Hangzhou, China.
Protein Sci. 2020 May;29(5):1120-1137. doi: 10.1002/pro.3849. Epub 2020 Mar 19.
Histone methylation, which is mediated by the histone lysine (K) methyltransferases (HKMTases), is a mechanism associated with many pathways in eukaryotes. Most HKMTases have a conserved SET (Su(var) 3-9,E(z),Trithorax) domain, while the HKMTases with SET domains are called the SET domain group (SDG) proteins. In plants, only SDG proteins can work as HKMTases. In this review, we introduced the classification of SDG family proteins in plants and the structural characteristics of each subfamily, surmise the functions of SDG family members in plant growth and development processes, including pollen and female gametophyte development, flowering, plant morphology and the responses to stresses. This review will help researchers better understand the SDG proteins and histone methylation in plants and lay a basic foundation for further studies on SDG proteins.
组蛋白甲基化由组蛋白赖氨酸（K）甲基转移酶（HKMTases）介导，是真核生物中许多途径相关的一种机制。大多数 HKMTases 具有保守的 SET（Su(var) 3-9、E(z)、Trithorax）结构域，而具有 SET 结构域的 HKMTases 则称为 SET 结构域组（SDG）蛋白。在植物中，只有 SDG 蛋白可以作为 HKMTases。在本文中，我们介绍了植物中 SDG 家族蛋白的分类和每个亚家族的结构特征，推测了 SDG 家族成员在植物生长发育过程中的功能，包括花粉和雌配子体发育、开花、植物形态和对胁迫的响应。本文的综述将有助于研究人员更好地理解植物中的 SDG 蛋白和组蛋白甲基化，并为进一步研究 SDG 蛋白奠定基础。
