College of Chemistry and Environmental Science, HeBei University, Baoding, Hebei, China.
Environ Int. 2012 Jul;42:132-7. doi: 10.1016/j.envint.2011.05.011. Epub 2011 Jun 12.
Some persistent organic pollutants (POPs) have been found in human semen but until this point it was unclear whether polybrominated diphenyl ethers (PBDEs) could be detected in human semen. In this study, PBDEs were found for the first time in human semen samples (n=101) from Taizhou, China. The concentrations of total PBDEs (∑PBDEs) varied from 15.8 to 86.8 pg/g ww (median=31.3 pg/g ww) and 53.2 to 121 pg/g ww (median=72.3 pg/g ww) in semen and blood samples, respectively. The ∑PBDE level in semen was about two times lower than in human blood, which was different in the distribution in the two matrices from other POPs. A correlation of ∑PBDE concentration was found between paired semen and in blood. The results suggest that semen could be used to detect PBDE burden in human body as a non-invasive matrix. In addition, the levels of BDE-209 and BDE-153, especially the latter, were much higher in blood than in semen, while the levels of BDE-28, BDE-47 and BDE-99 were comparable in the two matrices, suggesting that low brominated congeners could be more easily transferred to semen than high brominated congeners. Considering different toxicities among the PBDE congeners, it might be more significant to measure PBDEs in semen than in blood for evaluating male reproduction risks of PBDEs.
一些持久性有机污染物（POPs）已在人类精液中被发现，但直到目前为止，尚不清楚多溴二苯醚（PBDEs）是否可以在人类精液中被检测到。在这项研究中，首次在中国台州的人类精液样本（n=101）中发现了 PBDEs。总 PBDEs（∑PBDEs）的浓度在精液和血液样本中分别为 15.8 至 86.8 pg/g ww（中位数=31.3 pg/g ww）和 53.2 至 121 pg/g ww（中位数=72.3 pg/g ww）。精液中∑PBDE 的水平比人血中低约两倍，这与其他 POPs 在两种基质中的分布不同。在配对的精液和血液中发现了∑PBDE 浓度的相关性。结果表明，精液可作为非侵入性基质用于检测人体中 PBDE 的负担。此外，BDE-209 和 BDE-153 的水平，尤其是后者，在血液中的水平远高于精液，而 BDE-28、BDE-47 和 BDE-99 的水平在两种基质中相当，这表明低溴代同系物比高溴代同系物更容易转移到精液中。考虑到 PBDE 同系物之间存在不同的毒性，测量精液中的 PBDE 可能比测量血液中的 PBDE 更能评估 PBDE 对男性生殖的风险。
