Cognitive Neurology Unit, Rambam Health Care Campus, P.O. Box 9602, Haifa 31096, Israel.
Clin Neurophysiol. 2011 Dec;122(12):2390-9. doi: 10.1016/j.clinph.2011.05.010. Epub 2011 Jun 12.
To define the brain activity involved in impaired response inhibition of Attention Deficit Hyperactivity Disorder (ADHD) in adults.
Performance measures and brain activity of 14 adult ADHD subjects and 14 controls, matched for age, gender, and overall intelligence were compared in an auditory Go-NoGo paradigm to tones. The task required a button press (Go) to 80% and inhibition of response (NoGo) to 20% of the tones, according to the tone's pitch.
In NoGo trials ADHD subjects made significantly more commission errors compared to controls. ERPs of ADHD subjects showed smaller amplitudes of P3 (but not N2), and longer latencies of both N2 and P3. Source current density estimation revealed reduced activity in the right frontal dorsolateral cortex and in the posterior cingulate of the ADHD group. In addition, ADHD subjects showed an unexpected significantly enhanced response inhibition in Go trials, with excessive omission errors associated with significantly larger N2 amplitudes.
In ADHD the neural networks sub-serving response inhibition are impaired.
ADHD is a general dis-regulation of behavioral inhibition, not limited to response inhibition.
确定成人注意力缺陷多动障碍（ADHD）反应抑制受损所涉及的大脑活动。
在听觉 Go-NoGo 范式中，比较了 14 名成年 ADHD 受试者和 14 名匹配年龄、性别和整体智力的对照组对音调的表现测量和大脑活动。任务要求根据音调的音高，80%的情况下按按钮（Go），20%的情况下抑制反应（NoGo）。
在 NoGo 试验中，ADHD 受试者与对照组相比，明显犯更多的commission 错误。ADHD 受试者的 ERP 显示 P3 的振幅较小（但 N2 不明显），N2 和 P3 的潜伏期均较长。源电流密度估计显示，ADHD 组右侧额背外侧皮质和后扣带回的活动减少。此外，ADHD 受试者在 Go 试验中表现出出乎意料的过度抑制反应，与显著较大的 N2 振幅相关的过多遗漏错误。
在 ADHD 中，负责反应抑制的神经网络受损。
ADHD 是行为抑制的普遍失调，不仅限于反应抑制。
