Hoppen H J, Leenslag J W, Pennings A J, van der Lei B, Robinson P H
Department of Polymer Chemistry, University of Groningen, The Netherlands.
Biomaterials. 1990 May;11(4):286-90. doi: 10.1016/0142-9612(90)90012-f.
A synthetic biodegradable nerve guide was constructed of two polymeric layers: an inner microporous layer prepared from a copolymer of L-lactide and epsilon-caprolactone (pore size range 0.5-1 micron) and an outer microporous layer prepared from a polyurethane/poly(L-lactide) mixture (pore size range 30-70 microns). This nerve guide was used to bridge a 7 mm gap in the right sciatic nerve of rats. It enabled the sciatic nerve to regenerate across the gap, forming a new, well-defined nerve that effectively re-established the contact between the proximial and distal nerve end, as effective as an autograft.
内层微孔层由L-丙交酯和ε-己内酯的共聚物制备而成（孔径范围为0.5 - 1微米），外层微孔层由聚氨酯/聚（L-丙交酯）混合物制备而成（孔径范围为30 - 70微米）。该神经导管用于连接大鼠右侧坐骨神经7毫米的缺损处。它能使坐骨神经跨越缺损处再生，形成一条新的、界限清晰的神经，有效地重新建立近端和远端神经末梢之间的联系，效果与自体移植一样好。
