McGowan Institute for Regenerative Medicine, University of Pittsburgh, Bridgeside Point 2, 450 Technology Drive, Pittsburgh, PA 15219, USA.
Cell Tissue Res. 2012 Mar;347(3):759-74. doi: 10.1007/s00441-011-1185-7. Epub 2011 Jun 11.
Skeletal muscle has a robust capacity for regeneration following injury. However, few if any effective therapeutic options for volumetric muscle loss are available. Autologous muscle grafts or muscle transposition represent possible salvage procedures for the restoration of mass and function but these approaches have limited success and are plagued by associated donor site morbidity. Cell-based therapies are in their infancy and, to date, have largely focused on hereditary disorders such as Duchenne muscular dystrophy. An unequivocal need exists for regenerative medicine strategies that can enhance or induce de novo formation of functional skeletal muscle as a treatment for congenital absence or traumatic loss of tissue. In this review, the three stages of skeletal muscle regeneration and the potential pitfalls in the development of regenerative medicine strategies for the restoration of functional skeletal muscle in situ are discussed.
骨骼肌在受伤后具有很强的再生能力。然而，目前几乎没有任何有效的治疗方法可以用于治疗体积性肌肉损失。自体肌肉移植或肌肉移位代表了恢复质量和功能的可能挽救措施，但这些方法的成功率有限，并存在与供体部位相关的发病率。细胞疗法还处于起步阶段，迄今为止，主要集中在遗传性疾病，如杜氏肌营养不良症。明确需要再生医学策略，以增强或诱导功能性骨骼肌的新生形成，作为治疗先天性缺失或创伤性组织损失的方法。在这篇综述中，讨论了骨骼肌再生的三个阶段，以及在开发用于原位恢复功能性骨骼肌的再生医学策略中可能遇到的陷阱。
